ArticleTransfusion2017
Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report.
Article in Transfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 22 citations in OpenAlex.
- Childhood isolated C3d-positive AIHA: favorable prognosis but rare relapse or associated immunodeficiency.Blood advances · 2026Article
- Life-Threatening Recurrence of Paroxysmal Cold Hemoglobinuria in a Child During Influenza A Infection.Turkish archives of pediatrics · 2024Article
- The role of serological and molecular testing in the diagnostics and transfusion treatment of autoimmune haemolytic anaemia.Blood transfusion = Trasfusione del sangue · 2022Review
- How to use Donath-Landsteiner test to diagnose paroxysmal cold haemoglobinuria (PCH).Archives of disease in childhood. Education and practice edition · 2022Article
- Paroxysmal cold hemoglobinuria successfully treated with complement inhibition.Blood advances · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundParoxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath-Landsteiner antibody (D-L antibody). In children, this is typically a transient immune-mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D-L antibody is very rare. CASE REPORT: We have reported a unique case of recurrent PCH in a 5-year-old boy with two acute episodes of hemolysis separated by 21 months of hematologic remission. Each episode was severe requiring red blood cell transfusions, intravenous methylprednisolone, and intravenous immunoglobulin during the second episode. Testing identified recurrence of the D-L antibody with the classic anti-P biphasic hemolysis.
conclusionThis demonstrates that PCH can be a recurrent disease in the pediatric population (in the absence of syphilis) with the classical D-L antibody.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.