SynthesisActa psychiatrica Scandinavica2017
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.
Open access · greenAbstract readMeta-AnalysisMulticenter Study
In one paragraph
Synthesis in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
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56citing papers in PubMed, 5 pooled it
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What it found
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Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.Molecular psychiatry · 2022Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.Biological psychiatry · 2018Pooled it
- Brain Structure Measurements Predict Individualized Treatment Outcome of 12-Week Antipsychotic Monotherapies in First-episode Schizophrenia.Schizophrenia bulletin · 2023Trial
- Early deviations from normative brain morphology and cortical microstructure in schizophrenia spectrum disorders.Translational psychiatry · 2026Article
- An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Vertexwise Cortical Deviation Mapping (VCDM): A precision approach to cortical thickness assessment in non-affective psychosis.Brain imaging and behavior · 2026Article
- Schizophrenia Pathophysiology: Neurotransmitter Dysfunctions and Biomarker Frontiers.Current topics in medicinal chemistry · 2026Review
- Medication and atypical brain maturation in psychosis associated with long-term cognitive decline and symptom progression.The British journal of psychiatry : the journal of mental science · 2025Article
- Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study.BMC psychiatry · 2025Article
- Distributions and network changes of brain activity in the acute phase of anti-NMDAR encephalitis: a MEG study.Journal of neurology · 2025Article
- Resting-state functional connectivity correlates of brain structural aging in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri.Frontiers in human neuroscience · 2025Article
- Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles.Schizophrenia bulletin open · 2025Article
- A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models.Schizophrenia bulletin · 2024Article
- Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.Translational psychiatry · 2024Article
- Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis.Schizophrenia bulletin · 2024Article
- The Role of 3' Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia.Alpha psychiatry · 2024Article
Corrections and comments
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Authors and funding
60 authors at 20 institutions in 10 countries.
E WaltonDepartment of Psychology, Georgia State University, Atlanta, GA, USA.
D P HibarImaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
T G M van ErpDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
S G PotkinDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
R Roiz-SantiañezDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
B Crespo-FacorroDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
P Suarez-PinillaDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
N E M Van HarenDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
S M C de ZwarteDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
R S KahnDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
W CahnDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
N T DoanNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
K N JørgensenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-5751-4809
T P GurholtNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
I AgartzNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
O A AndreassenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
L T WestlyeNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
I MelleNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
A O BergNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
L Mørch-JohnsenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
A FaerdenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
L FlycktKarolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
H Fatouros-BergmanKarolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
Karolinska Schizophrenia Project Consortium (KaSP)
E G JönssonNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway.
R HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan.
H YamamoriDepartment of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
M FukunagaDivision of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
A PredaDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
P De RossiNESMOS Department (Neurosciences, Mental Health and Sensory Functions), School of Medicine and Psychology, Sapienza University, Rome, Italy.
F PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
N BanajLaboratory of Neuropsychiatry, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
V CiulloLaboratory of Neuropsychiatry, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
G SpallettaLaboratory of Neuropsychiatry, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
R E GurBrain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
R C GurBrain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
D H WolfBrain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
T D SatterthwaiteBrain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
L M BeardBrain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
I E SommerDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
S KoopsDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
O GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
A RichterSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
B KrämerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
S KellyImaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
G DonohoeSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
C McDonaldCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
D M CannonCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
A CorvinTrinity College, Dublin, Ireland.
M GillTrinity College, Dublin, Ireland.
A Di GiorgioSection of Psychiatry and Clinical Psychology, IRCCS Casa Sollievo della Sofferenza, S.G. Rotondo (FG), Italy.
A BertolinoPsychiatric Neuroscience Group, University of Bari 'Aldo Moro', Bari, Italy.
S LawrieDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, UK.
T NicksonDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, UK.
H C WhalleyDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, UK.
E NeilsonDivision of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, UK.
V D CalhounThe Mind Research Network, Albuquerque, NM, USA.
P M ThompsonImaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
J A TurnerDepartment of Psychology and Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
S EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
University Medical Center Utrecht · NLUniversity of Oslo · NOOslo University Hospital · NOUniversity of Pennsylvania · USHeidelberg University · DERoyal Edinburgh Hospital · GBFondazione Santa Lucia · ITUniversidad de Cantabria · ESUniversity of California, Irvine · USUniversity of Southern California · USGeorgia State University · USKarolinska Institutet · SEOllscoil na Gaillimhe – University of Galway · IEThe University of Osaka · JPTrinity College Dublin · IEBaylor College of Medicine · USCasa Sollievo della Sofferenza · ITCentro Ricerche Enrico Fermi · ITMind Research Network · USNational Institute for Physiological Sciences · JP
Funding
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MFUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0MMORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1MTheta and Gamma Oscillations in Cortical MicrocircuitsP50MH064045 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2001 to 2010
$21.6MULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4MBIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MMultivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8MSCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVET32MH019112 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1990 to 2024
$6.2MInformed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5MUnified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7MNCATS NIH HHS UL1 TR001414NCRR NIH HHS P41 RR014075NCRR NIH HHS U24 RR021382NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIBIB NIH HHS U54 EB020403NIMH NIH HHS K23 MH085096NIMH NIH HHS K23 MH098130NIMH NIH HHS P50 MH064045NIMH NIH HHS R01 MH101111NIMH NIH HHS R01 MH107703NIMH NIH HHS RC1 MH089257NIMH NIH HHS T32 MH019112
Abstract
objectiveBased on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.
methodThis prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.
resultsPositive symptom severity was negatively related to STG thickness in both hemispheres (left: β
conclusionOur findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
Indexed as
AdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleProspective StudiesPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyTemporal Lobecortical thicknessENIGMAFreeSurferMRIpositive and negative syndrome scalepositive symptomsscale for the assessment of positive symptomsschizophreniasuperior temporal gyrus
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