Evidence map›Paper›PMID 28369791›Full record

ArticleBritish journal of pharmacology2017

Activation of α

Cristina Arce, Diana Vicente, Vanessa Segura, Nicla Flacco, Fermi Montó, Luis Almenar, Jaime Agüero, Joaquín Rueda, Francesc Jiménez-Altayó, Elisabet Vila and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Corticosterone binds αHypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  3. Review
  4. Article
  5. Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries.International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
  8. Neryl butyrate induces contractile effects on isolated preparations of rat aorta.Naunyn-Schmiedeberg's archives of pharmacology · 2020
    Article
  9. Updates in the function and regulation of αBritish journal of pharmacology · 2019
    Review
  10. Activation of αBritish journal of pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Cristina ArceDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Diana VicenteDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Vanessa SeguraDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Nicla FlaccoDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Fermi MontóDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Luis AlmenarUnidad de Insuficiencia Cardiaca y Trasplantes, Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain.
Jaime AgüeroUnidad de Insuficiencia Cardiaca y Trasplantes, Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain.
Joaquín RuedaUnidad de Insuficiencia Cardiaca y Trasplantes, Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain.
Francesc Jiménez-AltayóFacultat de Medicina, Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Elisabet VilaFacultat de Medicina, Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Maria Antonia NogueraDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Pilar D'OconDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.ORCID 0000-0001-8544-7124
Maria Dolores IvorraDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Burjassot, Spain.
Universitat de València · ESHospital Universitari i Politècnic La Fe · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeA NO-mediated desensitization of vasoconstrictor responses evoked by stimulation of α EXPERIMENTAL APPROACH: Wistar and spontaneously hypertensive rats (SHR), 16, 32, 52 and 72 weeks-old, were used to evaluate the desensitization process. Expression of α KEY

resultsRepeated application of phenylephrine decreased subsequent α CONCLUSIONS AND IMPLICATIONS: The α

Indexed as

AgingAnimalsAorta, ThoracicDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedNitric Oxide Synthase Type IPhenylephrineRatsRats, Inbred SHRRats, WistarReceptors, Adrenergic, alpha-1Structure-Activity RelationshipNitric Oxide Synthase Type IPhenylephrineReceptors, Adrenergic, alpha-1

Identifiers

PMID28369791
PMCPMC5466529
OpenAlexW2603730066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.