ArticleToxicological sciences : an official journal of the Society of Toxicology2017
Editor's Highlight: OrganophosphateDiazinon Altered Quorum Sensing, Cell Motility, Stress Response, and Carbohydrate Metabolism of Gut Microbiome.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Pesticides: Unintended Impact on the Hidden World of Gut Microbiota.Metabolites · 2024Review
- Deciphering Gut Microbiome Responses upon Microplastic Exposure via Integrating Metagenomics and Activity-Based Metabolomics.Metabolites · 2023Article
- Impact of Pesticide Residues on the Gut-Microbiota-Blood-Brain Barrier Axis: A Narrative Review.International journal of molecular sciences · 2023Review
- Uptake of Soil-Residual Diazinon by Rotational Lettuce under Greenhouse Conditions.Foods (Basel, Switzerland) · 2022Article
- Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease.International journal of molecular sciences · 2022Review
- Raising the Alarm: Environmental Factors in the Onset and Maintenance of Chronic (Low-Grade) Inflammation in the Gastrointestinal Tract.Digestive diseases and sciences · 2022Review
- Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues.NPJ biofilms and microbiomes · 2021Article
- Environmental Occurrence, Toxicity Concerns, and Degradation of Diazinon Using a Microbial System.Frontiers in microbiology · 2021Review
- The Impact of Environmental Chemicals on the Gut Microbiome.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Endobolome, a New Concept for Determining the Influence of Microbiota Disrupting Chemicals (MDC) in Relation to Specific Endocrine Pathogenesis.Frontiers in microbiology · 2020Review
- Gut microbiome: An intermediary to neurotoxicity.Neurotoxicology · 2019Review
- Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice.Scientific reports · 2019Article
- Diet in Parkinson's Disease: Critical Role for the Microbiome.Frontiers in neurology · 2019Review
- Characterization of the Functional Changes in Mouse Gut Microbiome Associated with IncreasedACS omega · 2018Article
- Organophosphorus Compounds at 80: Some Old and New Issues.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- The Search for Environmental Causes of Parkinson's Disease: Moving Forward.Journal of Parkinson's disease · 2018Review
- Regular Wounding in a Natural System: Bacteria Associated With Reproductive Organs of Bedbugs and Their Quorum Sensing Abilities.Frontiers in immunology · 2017Article
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The gut microbiome plays a key role in energy production, immune system development, and host resistance against invading pathogens, etc. Disruption of gut bacterial homeostasis is associated with a number of human diseases. Several environmental chemicals have been reported to induce alterations of the gut microbiome. Diazinon, one of important organophosphate insecticides, has been widely used in agriculture. Diazinon and its metabolites are readily detected in different environmental settings and human urine. The toxicity of organophosphates has been a long-standing public health concern. We recently demonstrated that organophosphate insecticide diazinon perturbed the gut microbiome composition of mice. However, the functional impact of exposure on the gut microbiome has not been adequately assessed yet. In particular, the molecular mechanism responsible for exposure-induced microbial profile and community structure changes has not been identified. Therefore, in this study, we used metatranscriptomics to examine the effects of diazinon exposure on the gut metatranscriptome in C57BL/6 mice. Herein, we demonstrated for the first time that organophosphate diazinon modulated quorum sensing, which may serve as a key mechanism to regulate bacterial population, composition, and more importantly, their functional genes. In addition, we also found that diazinon exposure activated diverse stress response pathways and profoundly impaired energy metabolism of gut bacteria. These findings provide new understandings of the functional interplay between the gut microbiome and environmental chemicals, such as organophosphates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.