ArticleJournal of the Pediatric Infectious Diseases Society2018
Severe Parechovirus 3 Infections in Young Infants-Kansas and Missouri, 2014.
Article in Journal of the Pediatric Infectious Diseases Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Neonatal CNS Human Parechovirus Infections in Western Pennsylvania in the 2024 Season.Journal of medical virology · 2026Article
- Differences in Clinical Manifestations of Human Parechovirus-Related Meningitis in Neonates After the COVID-19 Pandemic: A Single-Center Exploratory Study.International journal of pediatrics · 2026Article
- Diagnosis, management, and outcomes of parechovirus infections in infants: an overview.Journal of clinical microbiology · 2024Review
- Human parechovirus meningitis in children: state of the art.Italian journal of pediatrics · 2023Review
- Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.Nature communications · 2023Article
- Human Parechovirus Associated Critical Illness in Neonates and Infants: Case Series and Review of Literature.Kansas journal of medicine · 2023Article
- Emergence of Parechovirus A3 as the Leading Cause of Central Nervous System Infection, Surpassing Any Single Enterovirus Type, in Children in Kansas City, Missouri, USA, from 2007 to 2016.Journal of clinical microbiology · 2021Article
- Year-Round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants.The Journal of pediatrics · 2021Article
- Review
- Review
- Host Immune Response to Enterovirus and Parechovirus Systemic Infections in Children.Open forum infectious diseases · 2020Article
- Parechovirus A Infections in Healthy Australian Children During the First 2 Years of Life: A Community-based Longitudinal Birth Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Review
- Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction-Based Testing.AJNR. American journal of neuroradiology · 2019Article
- Emergence of Parechovirus A4 Central Nervous System Infections among Infants in Kansas City, Missouri, USA.Journal of clinical microbiology · 2019Article
- High frequency and diversity of parechovirus A in a cohort of Malawian children.Archives of virology · 2019Article
- Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States.Emerging infectious diseases · 2019Article
- Enterovirus and Parechovirus Surveillance - United States, 2014-2016.MMWR. Morbidity and mortality weekly report · 2018Article
- A Case of Acute Hemorrhagic Necrotizing Encephalitis in the Neonatal Period: Case Report with Autopsy Findings.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyArticle
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundInfection with parechovirus type 3 (PeV3) can cause severe neurologic and sepsis-like illness in young infants; clinical and epidemiologic descriptions have been limited. We aimed to characterize PeV3 illness and explore risk factors for acquisition in a cluster of neonatal cases at Children's Mercy Hospital in Kansas City, Missouri.
methodsCerebrospinal fluid specimens were obtained from infants aged <180 days who were hospitalized with sepsis-like illness or meningitis between June 1 and November 1, 2014. PeV-positive specimens were sequenced at the Centers for Disease Control and Prevention. We reviewed the medical and birth charts of the infants and performed face-to-face parent interviews. We analyzed characteristics according to infant age and intensive care admission status.
resultsWe identified 35 cases of PeV infection in infants aged 5 to 56 days. Seven infants required intensive care (median age, 11 days vs 27 days among those who did not require intensive care; P = .0044). Six of these 7 infants had neurologic manifestations consistent with seizures, and all 6 of them were treated with acyclovir but subsequently tested negative for herpes simplex virus. Virus sequences formed 2 lineages, both of which were associated with severe illness. Half of the infants were reported to have household contacts who were ill during the week before onset. Infants aged ≤7 days at onset were more likely to have been delivered at the same hospital.
conclusionsPeV3 can cause severe neurologic illness in neonates, and younger infants are more likely to require intensive care. PeV3 should be considered along with herpes simplex virus and other pathogens when evaluating young infants with sepsis-like illness or meningitis. More widespread testing for PeV3 would enable us to gain a better understanding of the clinical scope and circulation of this virus.
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