ArticleInternational journal of epidemiology2017
Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project.
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Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Infancy and Childhood Obesity Grade Predicts Weight Loss in Adulthood: The ONTIME Study.Nutrients · 2021Trial
- The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- Longitudinal Changes in General Overweight and Obesity, and Central Obesity from Birth to Early Adolescence.Nutrients · 2026Article
- Food preparation skills and obesity risk in European children aged 6-9 years: a cross-sectional study using WHO COSI 2022-2024'.European journal of nutrition · 2026Article
- Associations of birth size with BMI trajectories and fluctuation across adolescence and adulthood: A longitudinal study of two Finnish twin cohorts.Early human development · 2025Article
- Children's birth weight and the risk of general obesity and central obesity in primary school children: a 4-year longitudinal study.Frontiers in public health · 2025Article
- Birth weight and cardiometabolic risk factors: a discordant twin study in the UK Biobank.Journal of developmental origins of health and disease · 2023Article
- Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.Human molecular genetics · 2022Article
- The Causal Evidence of Birth Weight and Female-Related Traits and Diseases: A Two-Sample Mendelian Randomization Analysis.Frontiers in genetics · 2022Article
- Association between birth weight and risk of abdominal obesity in children and adolescents: a school-based epidemiology survey in China.BMC public health · 2020Article
- Association of maternal prepregnancy weight and early childhood weight with obesity in adolescence: A population-based longitudinal cohort study in Japan.Pediatric obesity · 2020Article
- Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight.International journal of epidemiology · 2019Article
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study.BMC medical genetics · 2018Article
- Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.Early human development · 2018Article
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Authors and funding
66 authors.
Aline JelenkovicDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Yoshie YokoyamaDepartment of Public Health Nursing, Osaka City University, Osaka, Japan.
Reijo SundDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Programs Unit, University of Helsinki, Helsinki, Finland and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.
Yoon-Mi HurDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Meike BartelsDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Toos C E M van BeijsterveldtDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Syuichi OokiDepartment of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan.
Kimberly J SaudinoBoston University, Department of Psychological and Brain Sciencies, Boston, MA, USA.
Maria A StaziIstituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Corrado FagnaniIstituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Cristina D'IppolitoIstituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Tracy L NelsonDepartment of Health and Exercise Sciencies and Colorado School of Public Health, Colorado State University, USA.
Keith E WhitfieldPsychology and Neuroscience, Duke University, Durham, NC, USA.
Ariel Knafo-NoamThe Hebrew University of Jerusalem, Jerusalem, Israel.
David MankutaHadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel.
Lior AbramsonThe Hebrew University of Jerusalem, Jerusalem, Israel.
Kauko HeikkiläDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Tessa L CutlerThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
John L HopperThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
Jane WardleHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Clare H LlewellynHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Abigail FisherHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Brooke M HuibregtseInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Catherine A DeromCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Robert F VlietinckCentre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Morten Bjerregaard-AndersenBandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
Henning Beck-NielsenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Morten SodemannDepartment of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Adam D TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
David L TarnokiDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.
S Alexandra BurtMichigan State University, East Lansing, Michigan, USA.
Kelly L KlumpMichigan State University, East Lansing, Michigan, USA.
Juan R OrdoñanaDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Juan F Sánchez-RomeraIMIB-Arrixaca, Murcia, Spain.
Lucia Colodro-CondeDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Lise DuboisSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Michel BoivinSchool of Psycholoy, Laval University, Quebec, Canada.
Mara BrendgenDepartement of Psychology, University of Quebec at Montreal, Montreal, Quebec, Canada.
Ginette DionneSchool of Psycholoy, Laval University, Quebec, Canada.
Frank VitaroSchool of Psychoeducation, University of Montreal, Montreal, Quebec, Canada.
Jennifer R HarrisNorwegian Institute of Public Health, Oslo, Norway.
Ingunn BrandtNorwegian Institute of Public Health, Oslo, Norway.
Thomas Sevenius NilsenNorwegian Institute of Public Health, Oslo, Norway.
Jeffrey M CraigMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Richard SafferyMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Finn RasmussenDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Per TyneliusDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Gombojav BayasgalanHealthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Danshiitsoodol NarandalaiHealthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Claire M A HaworthMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Robert PlominKing's College London, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Fuling JiDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Feng NingDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Zengchang PangDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Esther RebatoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Shandell PahlenDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Thorkild I A SørensenNovo Nordisk Foundation Centre for Basic Metabolic Research (Section on Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jaakko KaprioDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Karri SilventoinenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Funding
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MResearch Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3MThe Effects of Estradiol on Genetic Risk for Disordered Eating During PubertyR01MH092377 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2010 to 2014
$3.4MA twin study of ovarian hormones and disordered eatingR01MH082054 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2008 to 2012
$3.1MDETERMINANTS OF BEHAVIORAL DEVELOPMENT IN CHILDRENR01HD010333 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WADSWORTH, SALLY J · 1985 to 2010
$3.0MDevelopmental Change in Temperament in Preschoolers: Implications and EtiologyR01HD068435 · NICHD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SAUDINO, KIMBERLY J. · 2012 to 2016
$2.9MADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9MIntegrating contextual, proximal, and individual risks for child conduct problemsR01HD066040 · NICHD · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2010 to 2014
$2.9MGenetic Influences on Activity Level in Early ChildhoodR01MH062375 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SAUDINO, KIMBERLY J. · 2003 to 2007
$1.9MGene-environment Interactions in Childhood Conduct ProblemsR01MH081813 · NIMH · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2008 to 2013
$1.6MAdolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2MHormones in Sex-different Developmental PsychopathologyR21MH070542 · NIMH · MICHIGAN STATE UNIVERSITY · PI NIGG, JOEL T · 2005 to 2007
$475kBiotechnology and Biological Sciences Research Council 31/D19086Cancer Research UK 14133Cancer Research UK C1418/A7974European Research Council 230374Medical Research Council G19/2Medical Research Council MR/M021475/1NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502NIA NIH HHS R01 AG013662NICHD NIH HHS R01 HD010333NICHD NIH HHS R01 HD066040NICHD NIH HHS R01 HD068435NIDA NIH HHS P60 DA011015NIDA NIH HHS T32 DA017637NIMH NIH HHS R01 MH062375NIMH NIH HHS R01 MH081813NIMH NIH HHS R01 MH082054NIMH NIH HHS R01 MH092377NIMH NIH HHS R03 MH063851NIMH NIH HHS R21 MH070542
Abstract
Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
Indexed as
Body Mass IndexAdolescentAdultBirth WeightChildChild, PreschoolFemaleHumansInfantInternationalityLinear ModelsMaleMiddle AgedTwins, DizygoticTwins, MonozygoticYoung Adultbirthweightbody mass indextwins
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