ArticleGenome biology and evolution2017
Comparative Genomics of Rhodococcus equi Virulence Plasmids Indicates Host-Driven Evolution of the vap Pathogenicity Island.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Plasmidial virulence of Rhodococcus equi and its implications of livestock infections for human health: a possible foodborne pathogen?Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Review
- Isolation of vapA-positive Rhodococcus equi from soil and fecal samples in Mongolia.The Journal of veterinary medical science · 2025Article
- Multi-host distribution of Rhodococcus equi (Prescottella equi) strains and their phylogenomic clustering.BMC microbiology · 2025Article
- Article
- In vitro susceptibility pattern of Rhodococcus equi isolated from patients to antimicrobials recommended exclusively to humans, to domestic animals and to both.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Isolation of vapB-positive Rhodococcus equi from submaxillary lymph nodes with or without granulomatous lesions in growing-finishing pigs in Japan.The Journal of veterinary medical science · 2024Article
- An Autobioluminescent Method for EvaluatingMicrobiology spectrum · 2022Article
- Genomic Characteristics Revealed Plasmid-Mediated Pathogenicity and Ubiquitous Rifamycin Resistance ofFrontiers in cellular and infection microbiology · 2022Article
- Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.Journal of clinical microbiology · 2021Article
- Responses to Ecopollutants and Pathogenization Risks of SaprotrophicPathogens (Basel, Switzerland) · 2021Review
- Spread of Multidrug-Resistant Rhodococcus equi, United States.Emerging infectious diseases · 2021Article
- Virulence Plasmids ofFrontiers in veterinary science · 2021Article
- Conservation ofInternational journal of systematic and evolutionary microbiology · 2020Article
- Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across EnvironmentalApplied and environmental microbiology · 2020Article
- Genomic analysis of a novel Rhodococcus (Prescottella) equi isolate from a bovine host.Archives of microbiology · 2019Article
- Article
- Ulcerative, granulomatous glossitis and enteritis caused byJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- The pathogenic actinobacterium Rhodococcus equi: what's in a name?Molecular microbiology · 2019Review
- Comparative Genomic Analysis ofInternational journal of genomics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The conjugative virulence plasmid is a key component of the Rhodococcus equi accessory genome essential for pathogenesis. Three host-associated virulence plasmid types have been identified the equine pVAPA and porcine pVAPB circular variants, and the linear pVAPN found in bovine (ruminant) isolates. We recently characterized the R. equi pangenome (Anastasi E, et al. 2016. Pangenome and phylogenomic analysis of the pathogenic actinobacterium Rhodococcus equi. Genome Biol Evol. 8:3140-3148.) and we report here the comparative analysis of the virulence plasmid genomes. Plasmids within each host-associated type were highly similar despite their diverse origins. Variation was accounted for by scattered single nucleotide polymorphisms and short nucleotide indels, while larger indels-mostly in the plasticity region near the vap pathogencity island (PAI)-defined plasmid genomic subtypes. Only one of the plasmids analyzed, of pVAPN type, was exceptionally divergent due to accumulation of indels in the housekeeping backbone. Each host-associated plasmid type carried a unique PAI differing in vap gene complement, suggesting animal host-specific evolution of the vap multigene family. Complete conservation of the vap PAI was observed within each host-associated plasmid type. Both diversity of host-associated plasmid types and clonality of specific chromosomal-plasmid genomic type combinations were observed within the same R. equi phylogenomic subclade. Our data indicate that the overall strong conservation of the R. equi host-associated virulence plasmids is the combined result of host-driven selection, lateral transfer between strains, and geographical spread due to international livestock exchanges.
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