ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Risk of Acute Coronary Heart Disease After Sepsis Hospitalization in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Sepsis in multimorbidity: a domain-based framework for systemic vulnerability and precision care.Frontiers in medicine · 2026Review
- Trained Immunity in sepsis: Exploring the molecular link to long-term cardiometabolic disorders.Immunologic research · 2025Review
- Long-term cardiovascular outcomes and risk factors in adult sepsis survivors: a systematic review and meta-analysis.World journal of emergency medicine · 2025Review
- A nomogram to predict 28-day mortality in patients with sepsis combined coronary artery disease: retrospective study based on the MIMIC-III database.Frontiers in medicine · 2024Article
- Combined Multiomics and In Silico Approach Uncovers PRKAR1A as a Putative Therapeutic Target in Multi-Organ Dysfunction Syndrome.ACS omega · 2023Article
- The potential role of SARS-CoV-2 infection in acute coronary syndrome and type 2 myocardial infarction (T2MI): Intertwining spread.Immunity, inflammation and disease · 2023Review
- Underestimated Ischemic Heart Disease in Major Adverse Cardiovascular Events after Septicemia Discharge.Medicina (Kaunas, Lithuania) · 2022Article
- Mechanisms of Post-critical Illness Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022Review
- Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death.The Yale journal of biology and medicine · 2019Review
- Impact of post-sepsis cardiovascular complications on mortality in sepsis survivors: a population-based study.Critical care (London, England) · 2019Article
- Resident Macrophages Orchestrating Heart Rate.Arquivos brasileiros de cardiologia · 2019Article
- Cardiovascular Events and Hospital Deaths Among Patients With Severe Sepsis.The American journal of cardiology · 2019Article
- Susceptible period for cardiovascular complications in patients recovering from sepsis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Sepsis is a preventable public health problem.Critical care (London, England) · 2018Article
- Protracted immune disorders at one year after ICU discharge in patients with septic shock.Critical care (London, England) · 2018Observational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Sepsis is associated with long-term health consequences. We sought to determine the long-term risks of acute and fatal coronary heart disease (CHD) events after sepsis hospitalizations among community-dwelling adults. Methods: We analyzed data from 30329 participants in the population-based REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. Sepsis events included hospitalizations for a serious infection with ≥2 systemic inflammatory response syndrome criteria. Acute CHD events included myocardial infarctions (MIs; nonfatal and fatal) and acute CHD deaths. Fatal CHD included deaths ≤28 days of an acute MI and acute CHD deaths. We age- and time-matched each sepsis participant with 5 nonsepsis participants. We assessed the associations between sepsis hospitalizations and future acute and fatal CHD events using Cox regression, Gray's model, and competing risks analysis, adjusting for comorbidities. Results: The matched cohort contained 1070 sepsis and 5350 nonsepsis participants. Risk of acute CHD was higher for sepsis than nonsepsis controls after adjusting for sex, race, education, income, region, tobacco use, and select chronic medical conditions (0-1 year adjusted hazard ratio [HR], 4.38 [95% confidence interval (CI), 2.03-9.45]; 1-4 years, 1.78 [1.09-2.88]; and 4+ years, 1.18 [0.52-2.67]). Risk of fatal CHD was similarly higher for sepsis than nonsepsis individuals (0-1 year adjusted HR, 3.12 [95% CI, 1.35-7.23]; 1-4 years, 3.29 [1.89-5.74]; and 4+ years HR, 1.15 [0.34-3.94]). Conclusions: The long-term risks of acute and fatal CHD are elevated after sepsis hospitalization. Management of acute CHD risk may be important for individuals surviving a sepsis event.
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Registered trials
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