ArticlePloS one2017
Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- YAP1 Is a Crucial Nexus in the Tumor Microenvironment.Current medical science · 2026Review
- Review
- Validation of Signal Intensity Gradient from TOF-MRA for Wall Shear Stress by Phase-Contrast MR.Journal of imaging informatics in medicine · 2024Article
- Mechanosensitive expression of the mesenchymal subtype marker connective tissue growth factor in glioblastoma.Scientific reports · 2022Article
- Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Hippo-Yap/Taz signalling in zebrafish regeneration.NPJ Regenerative medicine · 2022Review
- Distinctive Roles of YAP and TAZ in Human Endothelial Progenitor Cells Growth and Functions.Biomedicines · 2022Article
- YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells.Analytical cellular pathology (Amsterdam) · 2022Article
- An ATX-LPAiScience · 2021Article
- CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis.Journal of cell communication and signaling · 2021Review
- Inhibiting YAP in Endothelial Cells From Entering the Nucleus Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury.Frontiers in pharmacology · 2021Article
- P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis.Scientific reports · 2020Article
- Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature.Frontiers in oncology · 2020Review
- Remodeling of the Microvasculature: May the Blood Flow Be With You.Frontiers in physiology · 2020Review
- The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases.Frontiers in neuroscience · 2020Review
- Yes-associated protein 1 is required for proliferation and function of bovine granulosa cells in vitro†.Biology of reproduction · 2019Article
- Review
- Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis.Frontiers in cell and developmental biology · 2019Review
- Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research.Frontiers in cell and developmental biology · 2019Article
- Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.