ArticleProceedings of the National Academy of Sciences of the United States of America1988
Cloning of the gene encoding the delta subunit of the human T-cell receptor reveals its physical organization within the alpha-subunit locus and its involvement in chromosome translocations in T-cell malignancy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 99 citations in OpenAlex.
- Absence of TCL1A expression is a useful diagnostic feature in splenic marginal zone lymphoma.Virchows Archiv : an international journal of pathology · 2012Article
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- TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia.Journal of human genetics · 2006Article
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.Oncogene · 2000Article
- Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement.Molecular and cellular biology · 1997Article
- Role of T cell receptor delta gene in susceptibility to celiac disease.Journal of molecular medicine (Berlin, Germany) · 1996Article
- Identification of the TCL1 gene involved in T-cell malignancies.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Rearrangements of the human TCRD-deleting elements.Immunogenetics · 1994Article
- Chromosome walking on the TCL1 locus involved in T-cell neoplasia.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.Molecular and cellular biology · 1992Article
- Phenotypic and genotypic lineage switch of a lymphoma with shared chromosome translocation and T-cell receptor gamma gene rearrangement.Japanese journal of cancer research : Gann · 1992Article
- SacI polymorphism at the human TCR delta chain constant region (TCRD).Nucleic acids research · 1991Article
- Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas.The Journal of clinical investigation · 1991Article
- Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias.The Journal of clinical investigation · 1990Article
- Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.The Journal of experimental medicine · 1990Article
- Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Molecular cloning of the translocation breakpoint in T-ALL 11;14 (p13;q11): genomic map of TCR alpha and delta region on chromosome 14q11 and long-range map of region 11p13.Human genetics · 1989Article
- The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.Molecular and cellular biology · 1989Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
By taking advantage of "chromosomal walking" techniques, we have obtained clones that encompass the T-cell receptor (TCR) delta-chain gene. We analyzed clones spanning the entire J alpha region extending 115 kilobases 5' of the TCR alpha-chain constant region and have shown that the TCR delta-chain gene is located over 80 kilobases 5' of C alpha. TCR delta-chain gene is rearranged in the gamma/delta-expressing T-cell line Peer and is deleted in alpha/beta-expressing T-cell lines. Sequence analysis of portions of this genomic region demonstrates its identity with previously described cDNA clones corresponding to the C delta and J delta segments. Furthermore, we have analyzed a t(8;14)-(q24;q11) chromosome translocation from a T-cell leukemia and have shown that the J delta segment is rearranged in cells deriving from this tumor and probably directly involved in the translocation. Thus, the newly cloned TCR delta chain is implicated in the genesis of chromosome translocations in T-cell malignancies carrying cytogenetic abnormalities of band 14q11.
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