ArticleThe Journal of infectious diseases2017
Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Article
- Ectoparasitism and the gut microbiota: a cross-fostering experiment in a wild passerine.FEMS microbiology ecology · 2026Article
- A Coprological Investigation of Endoparasites in One-Horned Rhinoceros (Veterinary medicine international · 2026Article
- Prevalence of Intestinal Parasites in Captive Asian Elephants (Elephas maximus Linnaeus, 1758) in Central Nepal.Veterinary medicine and science · 2025Article
- Dynamics of Salmonella Dublin infection and antimicrobial resistance in a dairy herd endemic to salmonellosis.PloS one · 2025Article
- ConcurrentmSphere · 2024Article
- Systemic Immune Modulation by Gastrointestinal Nematodes.Annual review of immunology · 2024Review
- Trends and antibiotic susceptibility patterns of diarrhoeal pathogens - experience over 14 years in southern India.Access microbiology · 2024Article
- The impact of helminth-induced immunity on infection with bacteria or viruses.Veterinary research · 2023Review
- Networking between helminths, microbes, and mammals.Cell host & microbe · 2023Review
- Helminth-associated changes in host immune phenotype connect top-down and bottom-up interactions during co-infection.Functional ecology · 2023Article
- Chronic small intestinal helminth infection perturbs bile acid homeostasis and disrupts bile acid signaling in the murine small intestine.Frontiers in parasitology · 2023Article
- Infection with soil-transmitted helminths and their impact on coinfections.Frontiers in parasitology · 2023Review
- Effects of parasites coinfection with other pathogens on animal host: A literature review.Veterinary world · 2022Review
- Intestinal helminth infection transforms the CD4Mucosal immunology · 2022Article
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.PLoS pathogens · 2021Article
- Lectin-Mediated Bacterial Modulation by the Intestinal NematodeInternational journal of molecular sciences · 2021Article
- Infection withPathogens (Basel, Switzerland) · 2021Article
- Metabarcoding options to study eukaryotic endoparasites of birds.Ecology and evolution · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Intestinal helminth infections occur predominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of regulatory or type 2 (Th2) immune responses. Here we demonstrate an additional 3-way interaction in which helminth infection alters the metabolic environment of the host intestine to enhance bacterial pathogenicity. We show that an ongoing helminth infection increased colonization by Salmonella independently of T regulatory or Th2 cells. Instead, helminth infection altered the metabolic profile of the intestine, which directly enhanced bacterial expression of Salmonella pathogenicity island 1 (SPI-1) genes and increased intracellular invasion. These data reveal a novel mechanism by which a helminth-modified metabolome promotes susceptibility to bacterial coinfection.
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Registered trials
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