Evidence map›Paper›PMID 28368434›Full record

ArticleEndocrinology2017

The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice.

Rebecca E Harvey, Victor G Howard, Moyra B Lemus, Tara Jois, Zane B Andrews, Mark W Sleeman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Ghrelin system in Alzheimer's disease.Current opinion in neurobiology · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Ghrelin-induced multi-organ damage in mice fed obesogenic diet.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Article
  7. Physiological Effect of Ghrelin on Body Systems.International journal of endocrinology · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rebecca E HarveyDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Victor G HowardDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Moyra B LemusDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Tara JoisDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Zane B AndrewsDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Mark W SleemanDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia.
Monash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ghrelin plays a key role in appetite, energy homeostasis, and glucose regulation. Recent evidence suggests ghrelin suppresses inflammation in obesity; however, whether this is modulated by the acylated and/or des-acylated peptide is unclear. We used mice deficient in acylated ghrelin [ghrelin octanoyl-acyltransferase (GOAT) knockout (KO) mice], wild-type (WT) littermates, and C57BL/6 mice to examine the endogenous and exogenous effects of acyl and des-acyl ghrelin on inflammatory profiles under nonobese and obese conditions. We demonstrate that in the spleen, both ghrelin and GOAT are localized primarily in the red pulp. Importantly, in the thymus, ghrelin was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Acute exogenous treatment with acyl/des-acyl ghrelin suppressed macrophage numbers in spleen and thymus in obese mice, whereas only acyl ghrelin increased CD3+ T cells in the thymus in mice fed both chow and a high-fat-diet (HFD). Consistent with this result, macrophages were increased in the spleen of KO mice on a HFD. Whereas there was no difference in CD3+ T cells in the plasma, spleen, or thymus of WT vs KO mice, KO chow and HFD-fed mice displayed decreased leukocytes. Our results suggest that the acylation status affects the anti-inflammatory properties of ghrelin under chow and HFD conditions.

Indexed as

AcyltransferasesAnimalsDiet, High-FatGhrelinInflammationMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, ObeseObesitySpleenThymus GlandT-LymphocytesAcyltransferasesGhrelinghrelin, des-n-octanoylMboat4 protein, mouseMembrane Proteins

Identifiers

PMID28368434
PMCPMC5505216
OpenAlexW2598664670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.