Evidence map›Paper›PMID 28368420›Full record

ArticleOncogene2017

Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP

J S Frieling, G Shay, V Izumi, S T Aherne, R G Saul, M Budzevich, J Koomen, C C Lynch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J S FrielingDepartments of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
G ShayDepartments of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
V IzumiMolecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
S T AherneDepartments of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
R G SaulAntibody Characterization Lab, Leidos Biomedical Research, Frederick, MD, USA.
M BudzevichCancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
J KoomenMolecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
C C LynchDepartments of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Moffitt Cancer Center · USLeidos (United States) · USMolecular Oncology (United States) · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Host MMP-mediated regulation of the vicious cycle of prostate to bone metastasesR01CA143094 · NCI · VANDERBILT UNIVERSITY · PI LYNCH, CONOR C · 2010 to 2014
$1.5M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA143094
6 · The paper itself

Abstract

Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP

Indexed as

OsteogenesisAnimalsBone ResorptionCell DifferentiationCell LineCell MovementFemaleHumansMatrix MetalloproteinasesMiceOsteoblastsParathyroid Hormone-Related ProteinMatrix MetalloproteinasesParathyroid Hormone-Related Protein

Identifiers

PMID28368420
PMCPMC7771297
OpenAlexW2604887824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.