Evidence map›Paper›PMID 28368406›Full record

ArticleOncogene2017

Transcription factor SPZ1 promotes TWIST-mediated epithelial-mesenchymal transition and oncogenesis in human liver cancer.

L-T Wang, S-S Chiou, C-Y Chai, E Hsi, C-M Chiang, S-K Huang, S-N Wang, K K Yokoyama, S-H Hsu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Overexpression ofZoological research · 2022
    Article
  5. Article
  6. Article
  7. The effect of SiNPs on DNA methylation of genome in mouse spermatocytes.Environmental science and pollution research international · 2021
    Article
  8. Article
  9. Article
  10. [Twist regulates proliferation, migration and invasion of osteosarcoma cells in vitro].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
    Article
  11. Article
  12. Article
  13. Long Non-Coding RNA (LncRNA) HOXA11-AS Promotes Breast Cancer Invasion and Metastasis by Regulating Epithelial-Mesenchymal Transition.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

L-T WangGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
S-S ChiouDepartment of Pediatrics, Faculty of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
C-Y ChaiDepartment of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
E HsiDepartment of Genome Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
C-M ChiangDepartments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
S-K HuangDivision of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan.
S-N WangDivision of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
K K YokoyamaGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
S-H HsuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung Medical University · TWNational Health Research Institutes · TWThe University of Texas Southwestern Medical Center · US

Funding

E2-Cellular Complexes in HPV Chromatin TranscriptionR01CA103867 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHIANG, CHENG-MING · 2004 to 2017
$4.0M
NCI NIH HHS R01 CA103867
6 · The paper itself

Abstract

The epithelial-mesenchymal transition (EMT) is an important process in the progression of cancer. However, its occurrence and mechanism of regulation are not fully understood. We propose a regulatory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT through its transactivating ability in increasing TWIST1 expression. We compared the expression of SPZ1 and TWIST1 in specimens of hepatocarcinoma cells (HCCs) and non-HCCs. Expression of SPZ1 exhibited a tumor-specific expression pattern and a high correlation with patients' survival time, tumor size, tumor number and progression stage. Moreover, forced expression and knockdown of SPZ1 in hepatoma cells showed that SPZ1 was able to regulate the cellular proliferation, invasion, and tumorigenic activity in a TWIST1-dependent manner in vitro and in vivo. These data demonstrate that SPZ1, a newly dscribed molecule, transactivates TWIST1 promoters, and that this SPZ1-TWIST axis mediates EMT signaling and exerts significant regulatory effects on tumor oncogenesis.

Indexed as

Epithelial-Mesenchymal TransitionAdultAgedAged, 80 and overBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCarcinogenesisCarcinoma, HepatocellularCell Line, TumorCell ProliferationFemaleHumansLiver NeoplasmsMaleMiddle AgedNuclear ProteinsTwist-Related Protein 1Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsNuclear ProteinsSPZ1 protein, humanTWIST1 protein, humanTwist-Related Protein 1

Identifiers

PMID28368406
PMCPMC5543259
OpenAlexW2605324432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.