Evidence map›Paper›PMID 28368394›Full record

ArticleOncogene2017

Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis.

C-J Ko, S-W Lan, Y-C Lu, T-S Cheng, P-F Lai, C-H Tsai, T-W Hsu, H-Y Lin, H-Y Shyu, S-R Wu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Review
  8. The Role and Regulation of Thromboxane AMolecules (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  17. Article
  18. The Role of Cyclooxygenase-2 in Colorectal Cancer.International journal of medical sciences · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

C-J KoDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
S-W LanDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Y-C LuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
T-S ChengDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
P-F LaiDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
C-H TsaiAgricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
T-W HsuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
H-Y LinDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
H-Y ShyuBureau of Investigation, Ministry of Justice, Taipei, Taiwan.
S-R WuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
H-H LinDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
P-W HsiaoAgricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
C-H ChenDepartment of Urology, National Taiwan University Hospital, Taipei, Taiwan.
H-P HuangGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
M-S LeeDepartment of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
National Taiwan University · TWAgricultural Biotechnology Research Center, Academia Sinica · TWMinistry of Justice · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation plays an important role in cancer development and progression. Cyclooxygenases-2 (COX-2) is a key enzyme in generating prostaglandins causing inflammation, is often found to be overexpressed in prostate cancer (PCa) and is correlated with PCa cell invasion and metastasis. We aim to investigate the molecular mechanism of how COX-2 promotes PCa cell invasion and metastasis and to evaluate the effect of COX-2 inhibitors in a selected model of PCa progression. Our results showed that the expression of COX-2 and Interleukin 1β (IL-1β) was upregulated in highly invasive PCa cells and was correlated with the activated levels of membrane-anchored serine protease matriptase. The expression levels of COX-2 were increased and were correlated with matriptase levels in PCa specimens. Moreover, results showed that COX-2 overexpression or a COX-2 product Prostaglandin E

Indexed as

AnimalsCelecoxibCell MovementCyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneHEK293 CellsHumansInflammationInterleukin-2MaleMembrane ProteinsMiceMice, SCIDNeoplasm InvasivenessNeoplasm MetastasisCelecoxibCyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneInterleukin-2matriptase 2Membrane ProteinsPTGS2 protein, humanSerine EndopeptidasesSulindacsulindac sulfidesulindac sulfone

Identifiers

PMID28368394
OpenAlexW2604179032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.