Evidence map›Paper›PMID 28368042›Full record

ArticleScientific reports2017

A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy.

Adewale O Oladipo, Oluwatobi S Oluwafemi, Sandile P Songca, Ariunbuyan Sukhbaatar, Shiro Mori, Junnosuke Okajima, Atsuki Komiya, Shigenao Maruyama, Tetsuya Kodama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

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  14. Material design for lymph node drug delivery.Nature reviews. Materials · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Adewale O OladipoDepartment of Applied Chemistry, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, Johannesburg, South Africa.
Oluwatobi S OluwafemiDepartment of Applied Chemistry, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, Johannesburg, South Africa.
Sandile P SongcaDepartment of Chemistry, University of Zululand, PB X1001, KwaDlangezwa, 3886, South Africa.
Ariunbuyan SukhbaatarLaboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai 980-8575, Japan.
Shiro MoriLaboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai 980-8575, Japan.
Junnosuke OkajimaInstitute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577, Japan.
Atsuki KomiyaInstitute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577, Japan.
Shigenao MaruyamaInstitute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba Ward, Sendai, Miyagi 980-8577, Japan.
Tetsuya KodamaLaboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai 980-8575, Japan.
Tohoku University · JPUniversity of Johannesburg · ZATohoku University Hospital · JPUniversity of Zululand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve more efficient drug delivery for the treatment of lymph node metastasis. We show for the first time that polymeric gold nanorods (PAuNRs) can be delivered efficiently from an accessory axillary lymph node to a tumor-containing proper axillary lymph node, enabling effective treatment of lymph node metastasis. In a mouse model of metastasis, lymphatic spread of tumor was inhibited by lymphatic-delivered PAuNRs and near-infrared laser irradiation, with the skin temperature controlled by cooling. Unlike intravenous injection, lymphatic injection delivered PAuNRs at a high concentration within a short period. The results show that lymphatic administration has the potential to deliver anti-cancer agents to metastatic lymph nodes for inhibition of tumor growth and could be developed into a new therapeutic method.

Indexed as

Infrared RaysAnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalGoldLiposomesLymphatic MetastasisLymph NodesMiceNanotubesNeoplasmsPhototherapyTissue DistributionAntineoplastic AgentsGoldLiposomes

Identifiers

PMID28368042
PMCPMC5377366
OpenAlexW2604409111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.