Evidence map›Paper›PMID 28367974›Full record

ArticleScientific reports2017

Validation of a smartphone-based EEG among people with epilepsy: A prospective study.

Erica D McKenzie, Andrew S P Lim, Edward C W Leung, Andrew J Cole, Alice D Lam, Ani Eloyan, Damber K Nirola, Lhab Tshering, Ronald Thibert, Rodrigo Zepeda Garcia and 13 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 3 countries.

Erica D McKenzieDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Andrew S P LimDivision of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Edward C W LeungDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Andrew J ColeDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Alice D LamDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Ani EloyanDepartment of Biostatistics, School of Public Health, Brown University, Providence, RI, USA.
Damber K NirolaDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.
Lhab TsheringDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.
Ronald ThibertDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rodrigo Zepeda GarciaDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Esther BuiDivision of Neurology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
Sonam DekiDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.
Liesly LeeDivision of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Sarah J ClarkDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Joseph M CohenDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Jo MantiaDivision of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Kate T BrizziDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Tali R SoretsDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Sarah WahlsterDepartment of Neurology, University of Washington, Seattle, WA, USA.
Mia BorzelloDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Arkadiusz StopczynskiDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark.
Sydney S CashDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Farrah J MateenDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Massachusetts General Hospital · USBrown University · USHealth Sciences Centre · CASunnybrook Health Science Centre · CATechnical University of Denmark · DKToronto Western Hospital · CAUniversity of Manitoba · CAUniversity of Toronto · CAUniversity of Washington · US

Funding

CIHR CPG140200CIHR MSH136642
6 · The paper itself

Abstract

Our objective was to assess the ability of a smartphone-based electroencephalography (EEG) application, the Smartphone Brain Scanner-2 (SBS2), to detect epileptiform abnormalities compared to standard clinical EEG. The SBS2 system consists of an Android tablet wirelessly connected to a 14-electrode EasyCap headset (cost ~ 300 USD). SBS2 and standard EEG were performed in people with suspected epilepsy in Bhutan (2014-2015), and recordings were interpreted by neurologists. Among 205 participants (54% female, median age 24 years), epileptiform discharges were detected on 14% of SBS2 and 25% of standard EEGs. The SBS2 had 39.2% sensitivity (95% confidence interval (CI) 25.8%, 53.9%) and 94.8% specificity (95% CI 90.0%, 97.7%) for epileptiform discharges with positive and negative predictive values of 0.71 (95% CI 0.51, 0.87) and 0.82 (95% CI 0.76, 0.89) respectively. 31% of focal and 82% of generalized abnormalities were identified on SBS2 recordings. Cohen's kappa (κ) for the SBS2 EEG and standard EEG for the epileptiform versus non-epileptiform outcome was κ = 0.40 (95% CI 0.25, 0.55). No safety or tolerability concerns were reported. Despite limitations in sensitivity, the SBS2 may become a viable supportive test for the capture of epileptiform abnormalities, and extend EEG access to new, especially resource-limited, populations at a reduced cost.

Indexed as

ElectroencephalographyAdolescentAdultBhutanEpilepsyFemaleFollow-Up StudiesHumansMalePrognosisProspective StudiesSeizuresSmartphoneYoung Adult

Identifiers

PMID28367974
PMCPMC5377373
OpenAlexW2604879300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.