ArticleJournal of atherosclerosis and thrombosis2017
Asymptomatic Plaques of Lower Peripheral Arteries and Their Association with Cardiovascular Disease: An Autopsy Study.
Article in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Is breast arterial calcification associated with coronary artery disease?-A systematic review and meta-analysis.PloS one · 2020Pooled it
- The Impact of Stenosis Severity on Hemodynamic Parameters in the Iliac Artery: A Fluid-Structure Interaction Study.Bioengineering (Basel, Switzerland) · 2025Article
- Plasma copeptin and markers of arterial disorder in patients with type 2 diabetes, a cross-sectional study.Cardiovascular diabetology · 2024Article
- Genes Differentially Expressed Across Major Arteries Are Enriched in Endothelial Dysfunction-Related Gene Sets: Implications for Relative Inter-artery Atherosclerosis Risk.Bioinformatics and biology insights · 2024Article
- Underlying mechanisms of thrombus formation/growth in atherothrombosis and deep vein thrombosis.Pathology international · 2023Review
- Epidemiology of atherosclerotic cardiovascular disease in polygenic hypercholesterolemia with or without high lipoprotein(a) levels.Frontiers in cardiovascular medicine · 2023Article
- Ankle-brachial index predicts renal outcomes and all-cause mortality in high cardiovascular risk population: a nationwide prospective cohort study in CORE project.International urology and nephrology · 2022Article
- Article
- Risk of post-transplant cardiovascular events in kidney transplant recipients with preexisting aortoiliac stenosis.Clinical transplantation · 2022Article
- Atherosclerotic Plaque Burden on Abdominal CT: Automated Assessment With Deep Learning on Noncontrast and Contrast-enhanced Scans.Academic radiology · 2021Article
- Macroscopic Evaluation of Atherosclerosis in the Arteries: An Autopsy Assessment Tool.Arquivos brasileiros de cardiologia · 2021Article
- The Ankle-Brachial Index and Risk of Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2019Article
- Ankle-Brachial Index is a Predictor of Future Incident Chronic Kidney Disease in a General Japanese Population.Journal of atherosclerosis and thrombosis · 2019Article
- Relationship between symptomatic lower limb peripheral artery disease and calcified carotid artery plaque detected on panoramic images of neurologically asymptomatic males.Dento maxillo facial radiology · 2019Article
- Associations Between Plasma Betatrophin Levels and Coronary and Peripheral Artery Disease.Journal of atherosclerosis and thrombosis · 2019Article
- Inflammatory Mediators Across the Spectrum of Ankle-Brachial Index.Journal of atherosclerosis and thrombosis · 2019Article
- Low Plasma Levels of Fibroblast Growth Factor-21 in Patients with Peripheral Artery Disease.Journal of atherosclerosis and thrombosis · 2018Article
- Histopathology of Asymptomatic Iliac Atherosclerosis: From Autopsy to Practice.Journal of atherosclerosis and thrombosis · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPatients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority of patients with PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity artery plaques are associated with systemic atherosclerosis and the onset of cardiovascular disease (CVD) events using autopsy cases.
methodsWe histologically investigated the atherosclerotic plaques of the common iliac, common carotid, coronary, and renal arteries from 121 autopsy cases without symptoms of PAD (mean age:67.6 years; 63% men; 83% non-CVD death). We evaluated the relationship between the degree of iliac artery atherosclerosis and that of other arteries, and also the presence of any CVD, myocardial infarction, stroke, and renal failure.
resultsAdvanced atherosclerotic plaques (American Heart Association ≥4) were present in 86 (72%) common iliac arteries in these cases. These arteries also showed high frequencies of calcification (66%), intraplaque hemorrhage (42%), and plaque disruption (24%). These advanced lesions were associated with age (≥60 years), sex (male), hypertension, diabetes, and smoking habit (all P＜0.05). Additionally, it was significantly associated with CVD (odds ratio, 95% confidence interval; 6.2, 2.2-22), myocardial infarction (6.4, 1.2-19), stroke (8.7, 1.7-16), and renal failure/hemodialysis (5.8, 1.1-11). Cases with advanced iliac artery plaques had advanced coronary and carotid atherosclerosis.
conclusionThese results indicate that asymptomatic advanced plaques are frequently observed in common iliac arteries, and are associated with generalized atherosclerosis and CVD events.
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