ArticleJournal of the International Neuropsychological Society : JINS2017
Mild Cognitive Impairment Subtypes in a Cohort of Elderly Essential Tremor Cases.
Article in Journal of the International Neuropsychological Society : JINS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Trial
- Evaluation of Autonomic and Cognitive Functions in Patients with Essential Tremor.Neurology and therapy · 2026Article
- Predictors of Incident Dementia in a Cohort of Elders with Essential Tremor: A Prospective, Longitudinal Study.Neuro-degenerative diseases · 2026Article
- Clinical and kinematic characterization of parkinsonian soft signs in essential tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Analyses of correct responses and errors on measures of verbal fluency among Parkinson's disease and essential tremor patients.The Clinical neuropsychologist · 2023Article
- Can the Montreal Cognitive Assessment and Mini-Mental State Examination detect cognitive decline in elderly patients with essential tremor?The Clinical neuropsychologist · 2023Article
- Longitudinal study of clinical and neurophysiological features in essential tremor.European journal of neurology · 2023Article
- Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor.Frontiers in neurology · 2023Article
- Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson's disease versus essential tremor.Journal of clinical and experimental neuropsychology · 2022Article
- Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation.The Clinical neuropsychologist · 2022Article
- Motor features associated with cognition in non-demented individuals with essential tremor.Journal of the neurological sciences · 2022Article
- Depressive symptoms predict memory decline in Essential Tremor.Parkinsonism & related disorders · 2022Article
- Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.Journal of neuropathology and experimental neurology · 2021Article
- Mild cognitive impairment, dementia and risk of mortality in essential tremor: A longitudinal prospective study of elders.Journal of the neurological sciences · 2021Article
- How Human Single-Neuron Recordings Can Help Us Understand Cognition: Insights from Memory Studies.Brain sciences · 2021Review
- The "Caring Giver": Emotional Caregiving in the Setting of Essential Tremor.Research on aging · 2020Article
- Profiles of Normal Cognition in Essential Tremor.Journal of the International Neuropsychological Society : JINS · 2020Article
- Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.Human brain mapping · 2019Article
- Tremor Distribution and the Variable Clinical Presentation of Essential Tremor.Cerebellum (London, England) · 2019Article
- Mind the gaps: What we don't know about cognitive impairment in essential tremor.Parkinsonism & related disorders · 2019Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesIndividuals with essential tremor (ET) exhibit a range of cognitive deficits generally conceptualized as "dysexecutive" or "fronto-subcortical," and thought to reflect disrupted cortico-cerebellar networks. In light of emerging evidence that ET increases risk for Alzheimer's disease (AD), it is critical to more closely examine the nature of specific cognitive deficits in ET, with particular attention to amnestic deficits that may signal early AD.
methodsWe performed a cross-sectional analysis of baseline data from 128 ET cases (age 80.4±9.5 years) enrolled in a longitudinal, clinical-pathological study. Cases underwent a comprehensive battery of motor-free neuropsychological tests and a functional assessment to inform clinical diagnoses of normal cognition (ET-NC), mild cognitive impairment (MCI) (ET-MCI), or dementia (ET-D). ET-MCI was subdivided into subtypes including: amnestic single-domain (a-MCI), amnestic multi-domain (a-MCI+), non-amnestic single-domain (na-MCI), or non-amnestic multi-domain (na-MCI+).
resultsNinety-one (71.1%) cases were ET-NC, 24 (18.8%) were ET-MCI, and 13 (10.2%) were ET-D. Within MCI, the a-MCI+ subtype was the most common (13/24; 54.2%) followed by a-MCI (4/24; 16.7%), na-MCI+ (4/24; 16.7%), and na-MCI (3/24; 12.5%). Cases with amnestic MCI demonstrated lower recognition memory Z-scores (-2.4±1.7) than non-amnestic groups (-0.9±1.2) (p=.042).
conclusionsAmnestic MCI, defined by impaired memory recall but associated with lower memory storage scores, was the most frequent MCI subtype in our study. Such impairment has not been explicitly discussed in the context of ET and may be an early hallmark of AD. Results have implications for the prognosis of specific cognitive deficits in ET. (JINS, 2017, 23, 390-399).
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