ArticleEpidemiology and infection2017
Epidemics and aetiology of hand, foot and mouth disease in Xiamen, China, from 2008 to 2015.
Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease.BMC infectious diseases · 2019Trial
- Trial
- Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021.Infectious medicine · 2024Article
- Non-linear association between daily mean temperature and children's hand foot and mouth disease in Chongqing, China.Scientific reports · 2023Article
- Current status of hand-foot-and-mouth disease.Journal of biomedical science · 2023Review
- Identification of a neutralizing linear epitope within the VP1 protein of coxsackievirus A10.Virology journal · 2022Article
- Molecular Epidemiology of Herpangina Children in Tongzhou District, Beijing, China, During 2019-2020.Frontiers in medicine · 2022Article
- Evaluation of the cross-neutralization activities elicited by Coxsackievirus A10 vaccine strains.Human vaccines & immunotherapeutics · 2021Article
- Viral Infections and Cutaneous Drug-Related Eruptions.Frontiers in pharmacology · 2020Review
- The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017.Scientific reports · 2019Article
- Recent advances on the role of host factors during non-poliovirus enteroviral infections.Journal of biomedical science · 2019Review
- miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9.Emerging microbes & infections · 2018Article
- Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo.Human vaccines & immunotherapeutics · 2018Article
- Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam.Emerging infectious diseases · 2018Article
- Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.Emerging infectious diseases · 2018Article
- Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016.Emerging microbes & infections · 2018Article
- Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.Emerging microbes & infections · 2018Article
- Hand, Foot and Mouth Disease: A Single Centre Retrospective Study of 403 New Cases and Brief Review of Relevant Indian Literature to Understand Clinical, Epidemiological, and Virological Attributes of a Long-Lasting Indian Epidemic.Indian dermatology online journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 8 years, human enteroviruses (HEVs) have caused 27 227 cases of hand, foot and mouth disease (HFMD) in Xiamen, including 99 severe cases and six deaths. We aimed to explore the molecular epidemiology of HFMD in Xiamen to inform the development of diagnostic assays, vaccines and other interventions. From January 2009 to September 2015, 5866 samples from sentinel hospitals were tested using nested reverse transcription PCR that targeted the HEV 5' untranslated region and viral protein 1 region. Of these samples, 4290 were tested positive for HEV and the amplicons were sequenced and genotyped. Twenty-two genotypes were identified. Enterovirus 71 (EV71) and coxsackieviruses A16, A6 and A10 (CA16, CA6 and CA10) were the most common genotypes, and there were no changes in the predominant lineages of these genotypes. EV71 became the most predominant genotype every 2 years. From 2013, CA6 replaced CA16 as one of the two most common genotypes. The results demonstrate the vast diversity of HFMD pathogens, and that minor genotypes are able to replace major genotypes. We recommend carrying-out long-term monitoring of the full spectrum of HFMD pathogens, which could facilitate epidemic prediction and the development of diagnostic assays and vaccines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.