ArticleJournal of biological rhythms2017
Are Individual Differences in Sleep and Circadian Timing Amplified by Use of Artificial Light Sources?
Article in Journal of biological rhythms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health.Molecular psychiatry · 2021Pooled it
- Blunted light exposure amplitudes in patients with opioid use disorder.Npj biological timing and sleep · 2026Article
- Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype.Sleep · 2026Article
- Who Needs Bright Light and When? Mapping the Interactions of Lighting Environments and Individual Differences in Circadian Light Sensitivity.Journal of biological rhythms · 2026Article
- Pilot feasibility testing of biomathematical model recommendations for personalising sleep timing in shift workers.Journal of sleep research · 2025Article
- Mapping the physiological changes in sleep regulation across infancy and young childhood.PLoS computational biology · 2024Article
- Article
- Predicting neurobehavioral performance of resident physicians in a Randomized Order Safety Trial Evaluating Resident-Physician Schedules (ROSTERS).Sleep health · 2024Article
- Article
- Measuring light regularity: sleep regularity is associated with regularity of light exposure in adolescents.Sleep · 2023Article
- Nurse rostering with fatigue modelling : Incorporating a validated sleep model with biological variations in nurse rostering.Health care management science · 2023Article
- Actigraphy-measured rest-activity circadian rhythm disruption in patients with advanced cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness.iScience · 2021Article
- The interindividual variability of sleep timing and circadian phase in humans is influenced by daytime and evening light conditions.Scientific reports · 2021Article
- The Effects of Genetic Background for Diurnal Preference on Sleep Development in Early Childhood.Nature and science of sleep · 2021Article
- Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents.International journal of molecular sciences · 2020Review
- Evening home lighting adversely impacts the circadian system and sleep.Scientific reports · 2020Article
- Sleep and circadian instability in delayed sleep-wake phase disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Integrating wearable data into circadian models.Current opinion in systems biology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Within the human population, there is large interindividual variability in the timing of sleep and circadian rhythms. This variability has been attributed to individual differences in sleep physiology, circadian physiology, and/or light exposure. Recent experimental evidence suggests that the latter is necessary to evoke large interindividual differences in sleep and circadian timing. We used a validated model of human sleep and circadian physiology to test the hypothesis that intrinsic differences in sleep and circadian timing are amplified by self-selected use of artificial light sources. We tested the model under 2 conditions motivated by an experimental study (Wright et al., 2013): (1) a "natural" light cycle, and (2) a "realistic" light cycle that included attenuation of light due to living indoors when natural light levels are high and use of electric light when natural light levels are low. Within these conditions, we determined the relationship between intrinsic circadian period (within the range of 23.7-24.6 h) and timing of sleep onset, sleep offset, and circadian rhythms. In addition, we simulated a work week, with fixed wake time for 5 days and free sleep times on weekends. Under both conditions, a longer intrinsic period resulted in later sleep and circadian timing. Compared to the natural condition, the realistic condition evoked more than double the variation in sleep timing across the physiological range of intrinsic circadian periods. Model predictions closely matched data from the experimental study. We found that if the intrinsic circadian period was long (>24.2 h) under the realistic condition, there was significant mismatch in sleep timing between weekdays and weekends, which is known as social jetlag. These findings indicate that individual tendencies to have very delayed schedules can be greatly amplified by self-selected modifications to the natural light/dark cycle. This has important implications for therapeutic treatment of advanced or delayed sleep phase disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.