ArticleJournal of computational neuroscience2017
Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study.
Article in Journal of computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.eLife · 2025Article
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons.Brain sciences · 2025Article
- Noise or signal? Spontaneous activity of dorsal horn neurons: patterns and function in health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons.Molecular psychiatry · 2023Article
- Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice.Cell reports · 2023Article
- Nonlinear relationship between CAN current andCognitive neurodynamics · 2022Article
- Effectiveness in the Block by Honokiol, a Dimerized Allylphenol fromInternational journal of molecular sciences · 2020Article
- Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray.eLife · 2020Article
- Neural mechanisms of social homeostasis.Annals of the New York Academy of Sciences · 2019Review
- Lower Affinity of Isradipine for L-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Dopamine (DA) neurons of the ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) fire spontaneous action potentials (APs) at slow, regular patterns in vitro but a detailed account of their intrinsic membrane properties responsible for spontaneous firing is currently lacking. To resolve this, we performed a voltage-clamp electrophysiological study in brain slices to describe their major ionic currents and then constructed a computer model and used simulations to understand the mechanisms behind autorhythmicity in silico. We found that vlPAG/DRN DA neurons exhibit a number of voltage-dependent currents activating in the subthreshold range including, a hyperpolarization-activated cation current (I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.