ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Using physiological biomarkers in forensic psychiatry: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Is the Psychopathic Brain an Artifact of Coding Bias? A Systematic Review.Frontiers in psychology · 2021Pooled it
- Functional neural correlates of psychopathy: a meta-analysis of MRI data.Translational psychiatry · 2020Pooled it
- A Systematic Literature Review of Neuroimaging of Psychopathic Traits.Frontiers in psychiatry · 2019Pooled it
- Cortical Structure in Relation to Empathy and Psychopathy in 800 Incarcerated Men.Biological psychiatry global open science · 2026Article
- Associations of brain structure with psychopathy.European archives of psychiatry and clinical neuroscience · 2026Article
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Cortical structure in relation to empathy and psychopathy in 800 incarcerated men.bioRxiv : the preprint server for biology · 2025Article
- Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents.Research on child and adolescent psychopathology · 2024Article
- Dark triad personality traits are associated with decreased grey matter volumes in 'social brain' structures.Frontiers in psychology · 2023Article
- Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.European child & adolescent psychiatry · 2021Article
- Psychopathy.Nature reviews. Disease primers · 2021Review
- Gray matter correlates of impulsivity in psychopathy and in the general population differ by kind, not by degree: a comparison of systematic reviews.Social cognitive and affective neuroscience · 2021Article
- Resting-state network topology characterizing callous-unemotional traits in adolescence.NeuroImage. Clinical · 2021Article
- Effect of Methylphenidate on Resting-State Connectivity in Adolescents With a Disruptive Behavior Disorder: A Double-Blind Randomized Placebo-Controlled fMRI Study.Frontiers in psychiatry · 2021Article
- Gray matter asymmetry in the orbitofrontal cortex in relation to psychopathic traits in adolescents.Journal of psychiatric research · 2021Article
- Psychopathy is associated with fear-specific reductions in neural activity during affective perspective-taking.NeuroImage · 2020Article
- [The contribution of forensic neuroscience to psychopathy].L'Encephale · 2020Review
- Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity.NeuroImage. Clinical · 2020Article
- Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.Frontiers in behavioral neuroscience · 2020Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPsychopathy is a mental health disorder characterized by callous and impulsive antisocial behavior, and is associated with a high incidence of violent crime, substance abuse, and recidivism. Recent studies suggest that the striatum may be a key component of the neurobiological basis for the disorder, though structural findings have been mixed and functional connectivity of the striatum in psychopathy has yet to be fully examined.
methodsWe performed a multimodal neuroimaging study of striatum volume and functional connectivity in psychopathy, using a large sample of adult male prison inmates (
resultsTotal PCL-R and Factor 2 scores (which index the impulsive/antisocial traits of psychopathy) were associated with larger striatal subnuclei volumes and increased volume in focal areas throughout the striatum, particularly in the nucleus accumbens and putamen bilaterally. Furthermore, at many of the striatal areas where volume was positively associated with Factor 2 scores, psychopathy severity was also associated with abnormal functional connectivity with other brain regions, including dorsolateral prefrontal cortex, ventral midbrain and other areas of the striatum. The results were not attributable to age, race, IQ, substance use history, or intracranial volume.
conclusionThese findings associate the impulsive/antisocial dimension of psychopathy with enlarged striatal subnuclei and aberrant functional connectivity between the striatum and other brain regions. Furthermore, the co-localization of volumetric and functional connectivity findings suggests that these neural abnormalities may be pathophysiologically linked.
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