Evidence map›Paper›PMID 28367411›Full record

ReviewCell journal

Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy.

Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 364 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
364citing papers in PubMed, 12 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04113135 nawithdrawnnot on this map

The Utilization of Yoga as a Therapeutic Tool to Promote Physical Activity Behavior Change and Improved Postural Control in Individuals With Multiple Sclerosis

TypeinterventionalSponsorWinston Salem State UniversityRan2020 to 2020Enrolled0ConditionsMultiple SclerosisArmsYoga, Control
NCT05080270 early_phase1completednot on this map

Feasibility Study of Tolerogenic Fibroblasts in Patients With Refractory Multiple Sclerosis

TypeinterventionalSponsorFibroBiologicsRan2020 to 2021Enrolled5ConditionsMultiple Sclerosis, Relapsing-Remitting, Multiple SclerosisArmsTolerogenic Fibroblasts
NCT06764563 narecruitingnot on this map

The Effect of a Mediterranean Diet on Quality of Life in Multiple Sclerosis Patients

TypeinterventionalSponsorTel-Aviv Sourasky Medical CenterRan2025 to 2028Enrolled140ConditionsMultiple SclerosisArmsMediterranean Medical Nutrition Therapy (counselling)
3 · Its place in the literature

Who cites it

364 citing papers in PubMed, 12 syntheses or guidelines pooled it, 681 citations in OpenAlex.

  1. Pooled it
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  3. Association between interleukin-10 gene polymorphisms and multiple sclerosis susceptibility: evidence from a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  13. Trial
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  18. Investigating theResearch in pharmaceutical sciences · 2026
    Article
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304 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nazem GhasemiDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Shahnaz RazaviDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Elham NikzadJesus Son of Mary Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction. Conventional therapies for MS are based on the use of anti-inflammatory and immunomodulatory drugs, but these treatments are not able to stop the destruction of nerve tissue. Thus, other strategies such as stem cell transplantation have been proposed for the treatment of MS. Overall, it is important that neurologists be aware of current information regarding the pathogenesis, etiology, diagnostic criteria, and treatment of MS. Thus, this issue has been discussed according to recent available information.

Indexed as

Cell TherapyDemyelinationEtiologyMultiple Sclerosis

Identifiers

PMID28367411
PMCPMC5241505
OpenAlexW2626436891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.