ArticlePakistan journal of medical sciences
Does obesity cause chronic inflammation? The association between complete blood parameters with body mass index and fasting glucose.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophils as indicators of obesity-associated inflammation: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.Journal of clinical medicine · 2026Article
- Evaluation of Systemic Inflammation in Children with Untreated Dental Caries.Oral health & preventive dentistry · 2025Article
- Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study.Journal of clinical medicine · 2025Article
- Flaxseed Reduces Cancer Risk by Altering Bioenergetic Pathways in Liver: Connecting SAM Biosynthesis to Cellular Energy.Metabolites · 2023Article
- Predictive Models of Muscle Strength in Older People with Type 2 Diabetes Mellitus.Clinical interventions in aging · 2023Article
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios of overweight children and adolescents.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Observational
- Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China.Journal of translational medicine · 2019Article
- Sociodemographic and lifestyle factors associated with the neutrophil-to-lymphocyte ratio.Annals of epidemiology · 2019Article
- Long-term Results of Bariatric Surgery for Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis Treatment in Morbidly Obese Japanese Patients.Obesity surgery · 2019Article
- Metabolomic fingerprint of coronary blood in STEMI patients depends on the ischemic time and inflammatory state.Scientific reports · 2019Article
- Association Between BMI and Inflammation Among Diabetic Polyneuropathy Patients.International journal of preventive medicine · 2019Article
- Clinical Significance of Serum Bilirubin in Behçet's Disease.Journal of translational internal medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to determine the relationship of complete blood count (CBC) parameters and derivates with fasting blood sugar and the body mass index.
methodsThis was a prospective, observational clinical study. Hospitalized patients who received a physiotherapy program in the Physical Medicine and Rehabilitation Clinic between March and June 2016 were included. The age, height, weight, body mass index (BMI), fasting blood glucose, erythrocyte sedimentation (ESR), C-reactive protein, and CBC parameters (leukocytes, platelets, neutrophil, lymphocytes, and monocytes) and red cell distribution width, platelet distribution width, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio of the patients were recorded. The relationship between the BMI, fasting glucose, and CBC parameters and derivates were investigated. Patients were divided into groups based on BMI: BMI≤25 kg/m
resultsA significant difference in the lymphocyte count, ESR, and NLR values was observed among the three groups (P=0.011; P=0.021; P=0.04). A significant difference in NLR was found between groups 1 and 3 (P=0.04). Between groups 1 and 3, a significant difference in platelet count was noted (P=0.013). On dividing the patients into two groups: normal and overweight/obese, a significant difference in lymphocyte count, glucose, and ESR values was observed (P=0.038; P=0.05; P=0.013). The lymphocyte count, ESR, and glucose values were found to be higher in the overweight group. According to Spearman's correlation analysis, the BMI and NLR values were found to be negatively correlated (P=0.029; r=.145); however, the lymphocyte count and ESR values were positively correlated (P=0.009; r=.173); (P=0.013; r=.182).
conclusionThis study found a negative correlation between the NLR and BMI values and a lower NLR value in the obese group compared with the normal group. The overweight group showed a higher lymphocyte count, thereby confirming the positive correlation of lymphocyte count with BMI. A comprehensive clarification of the mechanisms underlying the relationship between obesity and inflammation may allow developing treatment strategies to reduce the negative effects of obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.