ArticleCurrent genomics2017
Genetic Imbalance in Patients with Cervical Artery Dissection.
Article in Current genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case-Control Study.Annals of clinical and translational neurology · 2026Article
- Safety of Physical Activity After Cervical Artery Dissection.European journal of neurology · 2026Observational
- GWAS-based polygenic risk scoring for predicting cerebral artery dissection in the Chinese population.BMC neurology · 2024Article
- Unraveling the Links between Chronic Inflammation, Autoimmunity, and Spontaneous Cervicocranial Arterial Dissection.Journal of clinical medicine · 2023Review
- Cervical Artery Dissection and Patent Foramen Ovale in Juvenile Stroke: Causality or Casuality? A Familiar Case Report.Medical sciences (Basel, Switzerland) · 2023Article
- Genetics of spontaneous cervical and coronary artery dissections.Frontiers in global women's health · 2023Review
- A novel scatterplot-based method to detect copy number variation (CNV).Frontiers in genetics · 2023Article
- Multiple Arterial Dissections and Connective Tissue Abnormalities.Journal of clinical medicine · 2022Article
- Causality Association Between COVID-19 Infection and Aortic Dissection.Anatolian journal of cardiology · 2022Article
- Childhood stroke.Nature reviews. Disease primers · 2022Review
- Cervical Artery Dissection and Sports.Frontiers in neurology · 2021Article
- Article
- Prognostic alternative splicing signature in cervical squamous cell carcinoma.IET systems biology · 2020Article
- Rare genetic variants in patients with cervical artery dissection.European stroke journal · 2019Article
- Article
- Imaging of Carotid Dissection.Current pain and headache reports · 2019Review
- Copy Number Variation and Risk of Stroke.Stroke · 2018Review
- Familial aortic disease and a large duplication in chromosome 16p13.1.Molecular genetics & genomic medicine · 2018Article
- Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory condition.Journal of neurology · 2018Article
- Dissecating aneurysm of extracranial internal carotid artery presenting with Tapia syndrome in patient with essential thrombocythemia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic and environmental risk factors are assumed to contribute to the susceptibility to cervical artery dissection (CeAD). To explore the role of genetic imbalance in the etiology of CeAD, copy number variants (CNVs) were identified in high-density microarrays samples from the multicenter CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) study and from control subjects from the CADISP study and the German PopGen biobank. Microarray data from 833 CeAD patients and 2040 control subjects (565 subjects with ischemic stroke due to causes different from CeAD and 1475 disease-free individuals) were analyzed. Rare genic CNVs were equally frequent in CeAD-patients (16.4%; n=137) and in control subjects (17.0%; n=346) but differed with respect to their genetic content. Compared to control subjects, CNVs from CeAD patients were enriched for genes associated with muscle organ development and cell differentiation, which suggests a possible association with arterial development. CNVs affecting cardiovascular system development were more common in CeAD patients than in control subjects (p=0.003; odds ratio (OR) =2.5; 95% confidence interval (95% CI) =1.4-4.5) and more common in patients with a familial history of CeAD than in those with sporadic CeAD (p=0.036; OR=11.2; 95% CI=1.2-107).
conclusionThe findings suggest that rare genetic imbalance affecting cardiovascular system development may contribute to the risk of CeAD. Validation of these findings in independent study populations is warranted.
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