Evidence map›Paper›PMID 28366881›Full record

ArticleJournal of leukocyte biology2017

Substance P-mediated chemokine production promotes monocyte migration.

Sergei Spitsin, John Meshki, Angela Winters, Florin Tuluc, Tami D Benton, Steven D Douglas

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. A molecular systems architecture of asthma.Frontiers in immunology · 2026
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Neuroimmune interplay in kidney health and disease: Role of renal nerves.Autonomic neuroscience : basic & clinical · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Neuroimmune Pathophysiology in Asthma.Frontiers in cell and developmental biology · 2021
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sergei SpitsinDivision of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
John MeshkiDivision of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
Angela WintersDivision of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
Florin TulucDivision of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
Tami D BentonDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Steven D DouglasDivision of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA; douglas@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Cagla Akay Espinoza · 2013 to 2026
$23.5M
Project 5U01MH090325 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI DOUGLAS, STEVEN DANIEL · 2009 to 2013
$5.6M
Project 3: Targeting Neurokinin 1 ReceptorP01MH105303 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI LEWIS, MARK G. · 2014 to 2017
$4.3M
CD163 in HIV ImmunopathogenesisR21AI108296 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DOUGLAS, STEVEN DANIEL · 2013 to 2014
$446k
NIAID NIH HHS R21 AI108296NIMH NIH HHS P01 MH105303NIMH NIH HHS P30 MH097488NIMH NIH HHS U01 MH090325
6 · The paper itself

Abstract

The neuropeptide SP has physiologic and pathophysiologic roles in CNS and peripheral tissues and is involved in crosstalk between nervous and immune systems in various conditions, including HIV and SIV infection. Increased SP levels were demonstrated in plasma of HIV

Indexed as

AdultBlood-Brain BarrierBrainCell MovementChemokine CCL2ChemokinesCulture Media, ConditionedEndothelial CellsHumansMacrophagesMicrovesselsMonocytesSubstance PUp-RegulationCCL2 protein, humanChemokine CCL2ChemokinesCulture Media, ConditionedSubstance PHIVneuroAIDSneurocognitive impairmentneurokinin-1 receptor

Identifiers

PMID28366881
PMCPMC5346177
OpenAlexW2533044245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.