Evidence map›Paper›PMID 28366838›Full record

ArticleResearch in microbiology

Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma.

Raina Fichorova, Jorge Fraga, Paola Rappelli, Pier Luigi Fiori

Abstract read
In one paragraph

Article in Research in microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impact of pH andProceedings of the National Academy of Sciences of the United States of America · 2026
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  4. Article
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  6. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Effect of essential oils fromFrontiers in parasitology · 2025
    Article
  12. Article
  13. Prevalence ofMicroorganisms · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Pathogens (Basel, Switzerland) · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raina FichorovaLaboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. Electronic address: rfichorova@rics.bwh.harvard.edu.
Jorge FragaLaboratory of Molecular Biology, Department of Parasitology, Institute of Tropical Medicine "Pedro Kouri", Autopista Novia del Mediodía km 61/2, La Lisa 17100, Havana, Cuba. Electronic address: jorgefragan@gmail.com.
Paola RappelliDepartment of Biomedical Sciences, University of Sassari, Viale S. Pietro 43B, 07100 Sassari, Italy. Electronic address: rappelli@uniss.it.
Pier Luigi FioriDepartment of Biomedical Sciences, University of Sassari, Viale S. Pietro 43B, 07100 Sassari, Italy. Electronic address: fioripl@uniss.it.

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
Molecular T. vaginalis-host interactions in relevance to inflammatory sequelaeR01AI079085 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FICHOROVA, RAINA N. · 2009 to 2012
$3.0M
T. vaginalis viruses as mucosal immunity modifiers with impact on women's healthR56AI091889 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FICHOROVA, RAINA N. · 2012 to 2012
$877k
T. vaginalis viruses as mucosal immunity modifiers with impact on women's healthRC1AI086788 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FICHOROVA, RAINA N. · 2010 to 2010
$499k
Trichomonas Lipophosphoglycan in Regulation Immune ResponsesR21HD054451 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI FICHOROVA, RAINA N. · 2007 to 2008
$450k
NIAID NIH HHS R01 AI079085NIAID NIH HHS R56 AI091889NIAID NIH HHS RC1 AI086788NICHD NIH HHS P30 HD018655NICHD NIH HHS R21 HD054451
6 · The paper itself

Abstract

Trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. This review focuses on symbiotic Trichomonasvirus and mycoplasmas carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. Improved diagnostics and larger clinical interventional studies are needed to confirm the causative role of protozoan symbionts in the variable clinical presentation of trichomoniasis and its morbid sequelae, including adverse reproductive outcome, susceptibility to viral infections and cancer.

Indexed as

FemaleHumansMycoplasmaTotiviridaeTrichomonasTrichomonas vaginalisTrichomonas VaginitisVaginaVaginitisCandidatus Mycoplasma girerdiidsRNA virusesEndosymbiontsMicrobiomeMycoplasma hominisTrichomoniasis

Identifiers

PMID28366838
PMCPMC8130574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.