Evidence map›Paper›PMID 28366781›Full record

ReviewClinical lymphoma, myeloma & leukemia2017

Waldenström Macroglobulinemia: Review of Pathogenesis and Management.

Seongseok Yun, Ariel C Johnson, Onyemaechi N Okolo, Stacy J Arnold, Ali McBride, Ling Zhang, Rachid C Baz, Faiz Anwer

Abstract readReview
In one paragraph

Review in Clinical lymphoma, myeloma & leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Mouse models of human multiple myeloma subgroups.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Lymphoplasmacytic Lymphoma with Only Lambda Light Chain Monoclonal Paraprotein Expression.European journal of case reports in internal medicine · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Seongseok YunDepartment of Medicine, University of Arizona, Tucson, AZ; Department of Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
Ariel C JohnsonUniversity of Arizona College of Medicine, Tucson, AZ.
Onyemaechi N OkoloDepartment of Medicine, University of Arizona, Tucson, AZ.
Stacy J ArnoldDivision of Pathology, Department of Medicine, University of Arizona, Tucson, AZ.
Ali McBrideCollege of Pharmacy, University of Arizona, Tucson, AZ.
Ling ZhangDepartment of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center, Tampa, FL.
Rachid C BazDepartment of Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
Faiz AnwerDivision of Hematology, Oncology, Blood, and Marrow Transplantation, Department of Medicine, University of Arizona, Tucson, AZ. Electronic address: anwerf@email.arizona.edu.
University of Arizona · USMoffitt Cancer Center · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007479 · NHLBI · UNIVERSITY OF ARIZONA · PI GEOFFREY C GURTNER, JAMES Kuang-Jan LIAO · 1985 to 2026
$4.4M
NCI NIH HHS P30 CA023074NHLBI NIH HHS T35 HL007479
6 · The paper itself

Abstract

Waldenström macroglobulinemia (WM) is a low-grade B-cell clonal disorder characterized by lymphoplasmacytic bone marrow involvement associated with monoclonal immunoglobulin M. Although WM remains to be an incurable disease with a heterogeneous clinical course, the recent discovery of mutations in the MYD88 and CXCR4 genes further enhanced our understanding of its pathogenesis. Development of new therapies including monoclonal antibodies, proteasome inhibitors, and Bruton tyrosine kinase inhibitors have made the management of WM increasingly complex. Treatment should be tailored to the individual patient while considering many clinical factors. The clinical outcomes are expected to continue to improve, given the emergence of novel therapeutics and better understanding of the underlying pathogenesis.

Indexed as

Antineoplastic AgentsHumansWaldenstrom MacroglobulinemiaAntineoplastic AgentsCXCR4Lymphoid neoplasmLymphoplasmacytic lymphomaMonoclonal immunoglobulin MMYD88

Identifiers

PMID28366781
PMCPMC5413391
OpenAlexW2594667125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.