ArticleCurrent biology : CB2017
Non-overlapping Neural Networks in Hydra vulgaris.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- In vivo replication of a fully functional nerve net in a clonally reproducing animal.Communications biology · 2026Article
- Control of water excretion in Hydra vulgaris by neural integration.Current biology : CB · 2026Article
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- FromCells · 2026Review
- A cybernetic framework for synthetic biological intelligence in the era of neural tissue engineering.Npj unconventional computing · 2026Review
- A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system.Development (Cambridge, England) · 2025Article
- Distributed neural computation and the evolution of the first brains.bioRxiv : the preprint server for biology · 2025Article
- Shedding Light on Patterns of Unconventional Expression of Opsin Genes in Hydra vulgaris.Integrative and comparative biology · 2025Article
- How Single-Cell Transcriptomics of Hydractinia Is Informing the Evolution of Cnidarian Sensory Systems.Integrative and comparative biology · 2025Review
- AnOpen biology · 2025Article
- The Bioelectrics of Immortality and Mortality in Cold-SensitiveBioelectricity · 2025Article
- Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by temperature and the microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neuronal Synchronization and Bidirectional Activity Spread Explain Efficient Swimming in a Whole-Body Model of Hydrozoan Jellyfish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Comparison of derivative-based and correlation-based methods to estimate effective connectivity in neural networks.Scientific reports · 2025Article
- Effect of temperature cycles on the sleep-like state in Hydra vulgaris.Zoological letters · 2025Article
- UnravelingFrontiers in bioengineering and biotechnology · 2025Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Terminal differentiation precedes functional circuit integration in the peduncle neurons in regenerating Hydra vulgaris.Neural development · 2024Article
- Dynamics of neural activity in early nervous system evolution.Current opinion in behavioral sciences · 2024Article
- Jellyfish for the study of nervous system evolution and function.Current opinion in neurobiology · 2024Review
23 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
To understand the emergent properties of neural circuits, it would be ideal to record the activity of every neuron in a behaving animal and decode how it relates to behavior. We have achieved this with the cnidarian Hydra vulgaris, using calcium imaging of genetically engineered animals to measure the activity of essentially all of its neurons. Although the nervous system of Hydra is traditionally described as a simple nerve net, we surprisingly find instead a series of functional networks that are anatomically non-overlapping and are associated with specific behaviors. Three major functional networks extend through the entire animal and are activated selectively during longitudinal contractions, elongations in response to light, and radial contractions, whereas an additional network is located near the hypostome and is active during nodding. These results demonstrate the functional sophistication of apparently simple nerve nets, and the potential of Hydra and other basal metazoans as a model system for neural circuit studies.
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