Evidence map›Paper›PMID 28366321›Full record

ArticleSleep medicine2017

Sleep in women undergoing in vitro fertilization: a pilot study.

Cathy A Goldstein, Michael S Lanham, Yolanda R Smith, Louise M O'Brien

Registry-linked trialAbstract read
In one paragraph

Article in Sleep medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06139757 (Sleep Length and Euploid Embryo Transfer Prospective Study), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06139757 completednot on this mapstarted 2024, after this paper: background citation

Sleep Length and Euploid Embryo Transfer Prospective Study

TypeobservationalSponsorNorthwestern UniversityRan2024 to 2025Enrolled150ConditionsInfertility, FemaleArmsOura ring
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  20. Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cathy A GoldsteinSleep Disorders Center, Department of Neurology, University of Michigan Health System, 1500 East Medical Center Drive, Med Inn C728, Ann Arbor, MI 48109-5845, USA. Electronic address: cathygo@med.umich.edu.
Michael S LanhamDepartment of Obstetrics & Gynecology, University of Michigan Health System, Von Voigtlander Women's Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
Yolanda R SmithDepartment of Obstetrics & Gynecology, University of Michigan Health System, Von Voigtlander Women's Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
Louise M O'BrienSleep Disorders Center, Department of Neurology, University of Michigan Health System, 1500 East Medical Center Drive, Med Inn C728, Ann Arbor, MI 48109-5845, USA; Department of Obstetrics & Gynecology, University of Michigan Health System, Von Voigtlander Women's Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
NCATS NIH HHS UL1 TR000433
6 · The paper itself

Abstract

objectiveSleep disturbances are thought to be frequent in women undergoing IVF despite minimal research of this hypothesis. Our goal was to longitudinally assess sleep duration and disturbances in women undergoing IVF and assess impact of habitual sleep duration on oocytes retrieved, an important outcome in IVF.

methodsActigraphy and questionnaire batteries containing sleep and psychometric instruments were performed prior to and throughout 24 IVF cycles.

resultsTST <7 h was present in 46%, 57%, 69%, and 42% of baseline, stimulation, post-oocyte retrieval, and post-embryo transfer recordings. ESS >10 was noted in 24%, 33%, and 36% of cycles during baseline, stimulation, and post-embryo transfer. PSQI >5 was noted in 57%, 43%, and 29% of cycles during baseline, stimulation, and post-embryo transfer. TST (F = 2.95, p = 0.04) and ESS (F = 4.36, p = 0.02) were the only sleep metrics in which a significant main effect of time was found by mixed models analysis. The final linear regression model chosen by stepwise selection to best explain the variability in oocytes retrieved included anti-mullerian hormone, day three follicle stimulating hormone, and baseline TST and explained 40% of the variance in oocytes retrieved (adjusted R

conclusionsThis is the first study to describe, with subjective and objective measures, sleep disturbances present throughout the IVF cycle. Importantly, a trend towards a linear relationship between TST and oocytes retrieved was found in this pilot study. Sleep may be a modifiable target to improve outcomes in women undergoing IVF and further investigations are needed.

Indexed as

Fertilization in VitroOocyte RetrievalSleepActigraphyAdultFemaleHumansPilot ProjectsSurveys and QuestionnairesActigraphyInfertilityIn vitro fertilizationSleep duration

Identifiers

PMID28366321
PMCPMC5380145

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.