ArticleJournal of virology1988
Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB.
Article in Journal of virology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.Oncogene · 2003Article
- A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions.Journal of virology · 1996Article
- Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells.Journal of virology · 1995Article
- Disease specificity of kinase domains: the src-encoded catalytic domain converts erbB into a sarcoma oncogene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase.Journal of virology · 1995Article
- Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.Molecular and cellular biology · 1994Article
- Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity.Journal of virology · 1994Article
- EGF receptor in neoplasia and metastasis.Cancer metastasis reviews · 1993Review
- Induction of renal adenocarcinoma by a nonmutated erbB oncogene.Journal of virology · 1993Article
- Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.Molecular and cellular biology · 1992Article
- Alteration of the kinetic properties of the epidermal growth factor receptor tyrosine kinase by basic proteins.The Biochemical journal · 1992Article
- Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.Journal of virology · 1991Article
- Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Journal of virology · 1991Article
- Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.Molecular and cellular biology · 1990Article
- Transformation of chicken embryo fibroblasts by direct DNA transfection of single oncogenes: comparative analyses of src, erbB, myc, and ras.Journal of virology · 1990Article
- Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Avian erythroblastosis virus transforms a novel mast cell-basophil precursor target in the Japanese quail.Journal of virology · 1989Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Three new erbB transducing viruses generated during avian leukosis virus-induced erythroblastosis have been cloned and sequenced, and their transforming abilities have been analyzed. Provirus 9134 E1 expresses an amino-terminally truncated erbB product that is analogous to the proviral insertionally activated c-erbB gag-erbB fusion product. This virus efficiently induces erythroblastosis, but does not transform fibroblasts in vitro or induce sarcomas in vivo. In contrast, virus 9134 S3 expresses an erbB product identical to the erbB product of 9134 E1, with the exception of a large internal deletion located between the kinase domain and the putative autophosphorylation site, P1. Interestingly, this virus is no longer capable of inducing erythroblastosis, but can induce both fibrosarcomas and hemangiomas in vivo. Provirus 9134 F3 has sustained an approximately 23-amino-acid carboxy-terminal truncation and is capable of inducing both erythroblastosis and sarcomagenesis. This virus expresses an erbB product with the shortest carboxy-terminal truncation sufficient to reveal the sarcomagenic potential of this protein. The distinct transforming properties of these viruses indicate that different structural domains of the erbB product confer distinct disease specificities.
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