Evidence map›Paper›PMID 28366190›Full record

ArticleBMB reports2017

Structural characterization of As-MIF and hJAB1 during the inhibition of cell-cycle regulation.

Young-Hoon Park, Mi Suk Jeong, Ki-Tae Ha, Hak Sun Yu, Se Bok Jang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Young-Hoon ParkDepartment of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Korea.
Mi Suk JeongDepartment of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Korea.
Ki-Tae HaDepartment of Korean Medical Science, School of Korean Medicine and Korean Medicine Research Centre for Healthy Aging, Pusan National University, Yangsan 50612, Korea.
Hak Sun YuDepartment of Parasitology, School of Medicine, Pusan National University, Yangsan 50612, Korea.
Se Bok JangDepartment of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Korea.
Pusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. When MIF and JAB1 are bound to each other in various intracellular sites, MIF inhibits the positive regulatory effects of JAB1 on the activity of AP-1. The intestinal parasite, Anisakis simplex, has an immunomodulatory effect. The molecular mechanism of action of As-MIF and human JAB1 are poorly understood. In this study, As-MIF and hJAB1 were expressed and purified with high solubility. The structure of As-MIF and hJAB1 interaction was modeled by homology modeling based on the structure of Ace-MIF. This study provides evidence indicating that the MIF domain of As-MIF interacts directly with the MPN domain of hJAB1, and four structure-based mutants of As-MIF and hJAB1 disrupt the As-MIF-hJAB1 interaction. [BMB Reports 2017; 50(5): 269-274].

Indexed as

Amino Acid SequenceCell Cycle CheckpointsCell Cycle ProteinsCOP9 Signalosome ComplexCyclin-Dependent Kinase Inhibitor p27HumansIntracellular Signaling Peptides and ProteinsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsPeptide HydrolasesProtein BindingProtein DomainsProtein Structural ElementsTranscription Factor AP-1Tumor Suppressor Protein p53Cell Cycle ProteinsCOP9 Signalosome ComplexCOPS5 protein, humanCyclin-Dependent Kinase Inhibitor p27Intracellular Signaling Peptides and ProteinsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanPeptide HydrolasesTranscription Factor AP-1Tumor Suppressor Protein p53

Identifiers

PMID28366190
PMCPMC5458677
OpenAlexW2621273486

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.