ArticleJournal of the American Chemical Society2017
Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 108 citations in OpenAlex.
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- Aspartimide Modification in RiPP Natural Products.Biochemistry · 2026Review
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- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Hirocidins, Cytotoxic Metabolites from Streptomyces hiroshimensis, Induce Mitochondrion-Mediated Apoptosis.Angewandte Chemie (International ed. in English) · 2024Article
- Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancerRSC advances · 2024Article
- Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module.ACS chemical biology · 2023Article
- A highly quality genome sequence of Penicillium oxalicum species isolated from the root of Ixora chinensis in Vietnam.G3 (Bethesda, Md.) · 2023Article
- A genetic tool to express long fungal biosynthetic genes.Fungal biology and biotechnology · 2023Article
- Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining.Natural product reports · 2023Review
- Mining and characterization of the PKS-NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996.Microbial cell factories · 2022Article
- Genome-Based Analysis ofBiology · 2022Article
- Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels-Alderases.Fungal biology and biotechnology · 2022Review
- Branching and converging pathways in fungal natural product biosynthesis.Fungal biology and biotechnology · 2022Review
- Ligiamycins A and B, Decalin-Amino-Maleimides from the Co-Culture ofMarine drugs · 2022Article
- Discovery and biosynthesis of macrophasetins from the plant pathogen fungusFrontiers in microbiology · 2022Article
- Genome mining methods to discover bioactive natural products.Natural product reports · 2021Review
- Five Tetramic Acid Derivatives Isolated from the Iranian FungusBiomolecules · 2021Article
- Biosynthesis ofJournal of the American Chemical Society · 2021Article
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11 authors at 2 institutions in 2 countries.
Funding
Abstract
Fungal polyketide synthases (PKSs) can function collaboratively to synthesize natural products of significant structural diversity. Here we present a new mode of collaboration between a highly reducing PKS (HRPKS) and a PKS-nonribosomal peptide synthetase (PKS-NRPS) in the synthesis of oxaleimides from the Penicillium species. The HRPKS is recruited in the synthesis of an olefin-containing free amino acid, which is activated and incorporated by the adenylation domain of the PKS-NRPS. The precisely positioned olefin from the unnatural amino acid is proposed to facilitate a scaffold rearrangement of the PKS-NRPS product to forge the maleimide and succinimide cores of oxaleimides.
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