Evidence map›Paper›PMID 28365917›Full record

ArticleDigestive diseases and sciences2017

The Protective Effects of Helix B Surface Peptide on Experimental Acute Liver Injury Induced by Carbon Tetrachloride.

Shengdi Wu, Cheng Yang, Nuo Xu, Lingyan Wang, Yun Liu, Jiyao Wang, Xizhong Shen

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Shengdi WuDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Cheng YangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Nuo XuDepartment of Respiration, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lingyan WangShanghai Key Laboratory of Organ Transplantation, Shanghai, 200032, China.
Yun LiuDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiyao WangDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xizhong ShenDepartment of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. xizhongshen@126.com.
Sun Yat-sen University · CNFudan University · CNShanghai Institute of Hematology · CNShanghai Institute of Organic Chemistry · CNThe First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the protective effects of helix B surface peptide (HBSP) on acute liver injury induced by carbon tetrachloride (CCl

methodsHBSP (8 nmol/kg) was intraperitoneally injected into C57 BL/6 mice 2 h after CCl

resultsHBSP significantly decreased serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and pro-inflammatory cytokines in liver tissues after CCl

conclusionsHBSP is a potential therapeutic agent against acute liver injury induced by CCl

Indexed as

Alanine TransaminaseAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticApoptosisAspartate AminotransferasesCarbon TetrachlorideCD3 ComplexCD68 MoleculeCD8 AntigensCell LineCell SurvivalChemical and Drug Induced Liver InjuryChromonesCytokinesEnzyme Inhibitors2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAlanine TransaminaseAntigens, CDAntigens, Differentiation, MyelomonocyticAspartate AminotransferasesCarbon TetrachlorideCD3 ComplexCD68 antigen, humanCD68 MoleculeCD8 AntigensChromonesCytokinesEnzyme InhibitorsErythropoietinglutaminyl-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serineGlutathione PeroxidaseL-Lactate DehydrogenaseMechanistic Target of Rapamycin Complex 1MorpholinesMultiprotein ComplexesPeptide FragmentsPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAcute liver injuryApoptosisHelix B surface peptideInflammation

Identifiers

PMID28365917
OpenAlexW2598386455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.