Evidence map›Paper›PMID 28365867›Full record

ArticleNeurochemical research2017

Inactivation of the Tuberomammillary Nucleus by GABA

Jun-Fan Xie, Kun Fan, Can Wang, Peng Xie, Min Hou, Le Xin, Guang-Fu Cui, Lin-Xin Wang, Yu-Feng Shao, Yi-Ping Hou

Abstract read
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In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jun-Fan XieDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Kun FanDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Can WangDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Peng XieDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Min HouDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Le XinDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Guang-Fu CuiDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Lin-Xin WangDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China.
Yu-Feng ShaoDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China. shaoyf@lzu.edu.cn.
Yi-Ping HouDepartment of Neuroscience, Anatomy, Histology and Embryology, Key laboratory of preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 199 Donggang Xi Road, Lanzhou, 730000, People's Republic of China. houyiping@lzu.edu.cn.
Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A prominent hypothesis, the "flip-flop switch" model, predicts that histaminergic (HAergic) neurons in the tuberomammillary nucleus (TMN), an important component of the ascending arousal system, are inactivated by GABA mainly from the ventrolateral preoptic nucleus to allow the appearance and maintenance of sleep. However, which sleep state and the band of EEG activity induced by GABAergic inactivation of the TMN are unclear. In this study, alterations of sleep-wake states and cortical EEG power spectral density were investigated following muscimol, a GABA

Indexed as

AnimalsElectroencephalographyGABA-A Receptor AgonistsHistamineHypothalamic Area, LateralInjections, IntraventricularMaleMuscimolRatsRats, Sprague-DawleyReceptors, GABA-ASleepWakefulnessGABA-A Receptor AgonistsHistamineMuscimolReceptors, GABA-AEEG power spectral densityGABAHistamineSleep-wake statesTuberomammillary nucleus

Identifiers

PMID28365867
OpenAlexW2603626136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.