Evidence map›Paper›PMID 28365851›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

The functional muscle-bone unit in children with cerebral palsy.

I Duran, F Schütz, S Hamacher, O Semler, C Stark, J Schulze, J Rittweger, E Schoenau

Abstract read
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Are there effects of age, gender, height, and body fat on the functional muscle-bone unit in children and adults?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I DuranCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany. Ibrahim.duran@unireha-koeln.de.ORCID http://orcid.org/0000-0003-4044-8822
F SchützCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany.
S HamacherInstitute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.
O SemlerCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany.
C StarkCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany.
J SchulzeCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany.
J RittwegerInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
E SchoenauCenter of Prevention and Rehabilitation, University of Cologne, Lindenburger Allee 44, 50931, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using only age- and height-adjusted bone mineral content (BMC) and areal bone mineral density (aBMD). When applying the functional muscle-bone unit diagnostic algorithm (FMBU-A), the prevalence of positive results decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP.

introductionThe prevalence of bone health deficits in children with cerebral palsy (CP) might be overestimated because age- and height-adjusted reference percentiles for bone mineral content (BMC) and areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry (DXA) do not consider reduced muscle activity. The aim of this study was to compare the prevalence of positive DXA-based indicators for bone health deficits in children with CP to the prevalence of positive findings after applying a functional muscle-bone unit diagnostic algorithm (FMBU-A) considering reduced muscle activity.

methodsThe present study was a monocentric retrospective analysis of 297 whole body DXA scans of children with CP. The prevalence of positive results of age- and height-adjusted BMC and aBMD defined as BMC and aBMD below the P3 percentile and of the FMBU-A was calculated.

resultsIn children with CP, the prevalence of positive results of age-adjusted BMC were 33.3% and of aBMD 50.8%. Height-adjusted results for BMC and aBMD were positive in 16.8 and 36.0% of cases. The prevalence of positive results applying the FMBU-A regarding BMC and aBMD were significantly (p < 0.001) lower than using age- and height-adjusted BMC and aBMD (8.8 and 14.8%).

conclusionsOur results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using age- and height-adjusted BMC and aBMD. When applying the FMBU-A, the prevalence decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP.

Indexed as

Absorptiometry, PhotonAdolescentBone DensityCerebral PalsyChildFemaleHumansMaleMuscle, SkeletalOsteoporosisRetrospective StudiesSeverity of Illness IndexSex FactorsYoung AdultCerebral palsyDual-energy X-ray absorptiometryFractureMuscle-bone interactionsOsteoporosis

Identifiers

PMID28365851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.