Evidence map›Paper›PMID 28365829›Full record

ArticleVirus genes2017

Newcastle disease virus-like particles induce dendritic cell maturation and enhance viral-specific immune response.

Jing Qian, Jiaxin Ding, Renfu Yin, Yixue Sun, Cong Xue, Xiaohong Xu, Jianzhong Wang, Chan Ding, Shengqing Yu, Xiufan Liu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jing QianLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Jiaxin DingLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Renfu YinLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Yixue SunEngineering Research Center of Jilin Province for Animals Probiotics, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Cong XueLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Xiaohong XuLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Jianzhong WangEngineering Research Center of Jilin Province for Animals Probiotics, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Chan DingShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Shengqing YuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Xiufan LiuAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Shunlin HuAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Yanlong CongLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. congyanlong@126.com.
Zhuang DingLaboratory of Infectious Diseases, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. dingzhuang@jlu.edu.cn.
Jilin University · CNJilin Agricultural University · CNShanghai Veterinary Research Institute · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating of genotype VII Newcastle disease virus (NDV) is a great threat to the poultry industry worldwide. Virus-like particles (VLPs) are increasingly being considered as potential viral vaccines due to their safety and efficacy. In this study, we analyzed in vitro the stimulatory effects of VLPs containing the matrix and hemagglutinin-neuraminidase of genotype VII NDV on dendritic cells (DCs) and evaluated their immunogenicity in mice. The results showed that immature bone marrow-derived dendritic cells (BMDCs) responded to stimulation with VLPs by up-regulating expressions of MHC II, CD40, CD80, and CD86 molecules and by increasing the cytokine secretions of TNF-α, IFN-γ, IL-6, and IL-12p70. Besides, VLPs enhanced the immunostimulatory capacity of DCs to stimulate autologous T cell proliferation. Furthermore, VLPs can induce efficient humoral and cellular immune responses, and recruit mature DCs to the spleen in C57BL/6 mice, as shown by an obvious increase in double-positive proliferation of splenic CD11c+CD86+ cells. These data indicate that NDV VLPs can be a valuable candidate for NDV vaccine development.

Indexed as

AnimalsAntibodies, ViralBone Marrow CellsCell ProliferationChickensCytokinesDendritic CellsFemaleGeeseImmunity, CellularInterleukin-6MiceMice, Inbred C57BLNewcastle DiseaseNewcastle disease virusPoultry DiseasesAntibodies, ViralCytokinesInterleukin-6Tumor Necrosis Factor-alphaDendritic cellImmune responseNewcastle disease virusVirus-like particle

Identifiers

PMID28365829
OpenAlexW2601797111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.