ArticleCerebral cortex (New York, N.Y. : 1991)2017
Distinct Roles for the Anterior Cingulate and Dorsolateral Prefrontal Cortices During Conflict Between Abstract Rules.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Coupling of Rhythms in Prefrontal Cortex and Autonomic Nervous System in School-Age Children.Annals of the New York Academy of Sciences · 2026Article
- Article
- The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study.Progress in neurobiology · 2020Article
- Glutamatergic Correlates of Bipolar Symptoms in Adolescents.Journal of child and adolescent psychopharmacology · 2020Article
- Emergence of abstract rules in the primate brain.Nature reviews. Neuroscience · 2020Review
- Jumping on the 'bad'wagon? How group membership influences responses to the social exclusion of others.Social cognitive and affective neuroscience · 2020Article
- Aberrant functional connectivity of the cingulate subregions in right-sided temporal lobe epilepsy.Experimental and therapeutic medicine · 2020Article
- Approach-Avoidance Conflict in Major Depressive Disorder: Congruent Neural Findings in Humans and Nonhuman Primates.Biological psychiatry · 2020Article
- The Role of Primate Prefrontal Cortex in Bias and Shift Between Visual Dimensions.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Causal Evidence for Learning-Dependent Frontal Lobe Contributions to Cognitive Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Distinct patterns of activity within the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (dlPFC) reported in neuroimaging studies during tasks involving conflict between competing responses have often been cited as evidence for their key contributions to conflict-monitoring and behavioral adaptation, respectively. However, supporting evidence from neuropsychological patients has been scarce and contradictory. We administered a well-studied analog of the Wisconsin Card Sorting Test, designed to elicit conflict between 2 abstract rules, to a cohort of 6 patients with damage to ACC or dlPFC. Patients who had sustained more significant damage to the ACC were not impaired either on a measure of "conflict cost" nor on measures of "conflict-induced behavioral adaptation." In contrast, damage to dlPFC did not affect the conflict cost measure but abolished the patients' ability to adapt their behavior following exposure to conflict, compared with controls. This pattern of results complements the findings from nonhuman primates with more circumscribed lesions to ACC or dlPFC on the same task and provides converging evidence that ACC is not necessary for performance when conflict is elicited between 2 abstract rules, whereas dlPFC plays a fundamental role in behavioral adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.