Trial reportHormone research in paediatrics2017
Determinants of Advanced Bone Age in Childhood Obesity .
Trial report in Hormone research in paediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- BMI-SDS Changes During GnRHa Therapy in 150 Girls with Idiopathic Central Precocious Puberty: Follow-up Through Final HeightJournal of clinical research in pediatric endocrinology · 2026Article
- Bone age evaluation in an ethnically diverse cohort of children with premature adrenarche.Pediatric research · 2026Article
- Bone age, predicted adult height and HOMA-IR in children and adolescents with overweight and obesity: a single-centre cross-sectional study.BMJ paediatrics open · 2026Article
- Independence of the body composition index from nutritional status affecting bone maturation.Pediatric research · 2026Article
- Adrenal androgen mediates the association between obesity and accelerated skeletal maturation in children and adolescents.Frontiers in endocrinology · 2026Article
- Sex, BMI, skeletal maturation, and height among children and adolescents in high-altitude Xizang: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Comparison of BoneXpert and IB-Lab-PANDA automated Bone Age Evaluation in Children With Growth and Puberty Disorders.Journal of the Endocrine Society · 2025Article
- Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche.Annals of pediatric endocrinology & metabolism · 2025Article
- Unraveling the relationship between head circumference and MC4R deficiency from infancy to adulthood: a case-control study.Obesity (Silver Spring, Md.) · 2025Article
- Obesity and Overweight Conditions in Children and Adolescents (6-18 Years) and Their Impact on Craniofacial Morphology: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Correlation of bone age development with overweight and obesity in 23,305 children from Beijing.Endocrine · 2025Article
- Body composition trajectories during childhood predict skeletal maturation at puberty: A longitudinal study.Heliyon · 2024Article
- 2022 Clinical practice guidelines for central precocious puberty of Korean children and adolescents.Annals of pediatric endocrinology & metabolism · 2023Article
- The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits.Nature reviews. Endocrinology · 2022Review
- Does coronavirus disease 2019 affect body mass index of children and adolescents who visited a growth clinic in South Korea?: a single-center study.Annals of pediatric endocrinology & metabolism · 2022Article
- Novel Genomic Variants, Atypical Phenotypes and Evidence of a Digenic/Oligogenic Contribution to Disorders/Differences of Sex Development in a Large North African Cohort.Frontiers in genetics · 2022Article
- An Approach to the Evaluation and Management of the Obese Child With Early Puberty.Journal of the Endocrine Society · 2022Review
- Analysis of the Relationship between Nutritional Status and Bone Age and Sexual Development in Children and Adolescents.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Factors affecting prepubertal and pubertal bone age progression.Frontiers in endocrinology · 2022Review
- Increased Incidence of Precocious Puberty in Girls During COVID-19 Pandemic: Early Indicator of the Upcoming Childhood Metabolic Syndrome Pandemic?Global pediatric health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach.
methodWe performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obese children. A multivariate analysis was performed to investigate which parameters were independently predictive of BA SDS.
resultsIn this cohort (n = 101; mean age 10.9 years; mean BA 11.8 years; mean BMI SDS 3.3), BMI SDS was significantly correlated to BA SDS (r = 0.55, p < 0.001). In a regression analysis in the total cohort (B = 0.27, p < 0.001) as well as in females (B = 0.34, p = 0.042), males (B = 0.31, p = 0.006), and pubertal children (B = 0.32, p = 0.046), dehydroepiandrosterone sulphate (DHEAS) showed a positive, independent association with BA SDS. No association with indicators of insulin secretion was found.
conclusionBMI SDS is highly correlated to BA SDS in obese children. Increased DHEAS has a central role in advanced BA in obese children. .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.