Evidence map›Paper›PMID 28365586›Full record

ArticleAmerican journal of physiology. Renal physiology2017

ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4

Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Junhui Zhang, Dao-Hong Lin, Wen-Hui Wang

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Familial Hyperkalemic Hypertension.Comprehensive Physiology · 2024
    Review
  4. Review
  5. Article
  6. Differentiated mouse kidney tubuloids as a novelFrontiers in cell and developmental biology · 2023
    Article
  7. Review
  8. Article
  9. WNK4 kinase: from structure to physiology.American journal of physiology. Renal physiology · 2021
    Review
  10. MST3 Involvement in NaInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary KAmerican journal of physiology. Renal physiology · 2018
    Article
  14. Article
  15. Dietary KPflugers Archiv : European journal of physiology · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chengbiao ZhangDepartment of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Lijun WangDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Xiao-Tong SuDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Junhui ZhangDepartment of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut.
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla, New York; Wenhui_wang@nymc.edu.
New York Medical College · USHoward Hughes Medical Institute · USXuzhou Medical College · CN

Funding

Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

Mice transgenic for genomic segments harboring PHAII (pseudohypoaldosteronism type II) mutant Wnk4 (with-No-Lysine kinase 4) (TgWnk4

Indexed as

AnimalsDisease Models, AnimalDown-RegulationEpithelial Sodium ChannelsFemaleGenetic Predisposition to DiseaseHyperkalemiaKidney Tubules, DistalLiddle SyndromeMaleMembrane PotentialsMice, Inbred C57BLMice, TransgenicPhenotypePotassiumPotassium Channels, Inwardly RectifyingEpithelial Sodium ChannelsKcnj1 protein, mousePotassiumPotassium Channels, Inwardly RectifyingPotassium, DietaryPrkwnk4 protein, mouseProtein Serine-Threonine KinasesScnn1b protein, mouseScnn1g protein, mousehyperkalemiaKir1.1Kir4.1K secretionpseudohypoaldosteronism type II

Identifiers

PMID28365586
PMCPMC5407067
OpenAlexW2551446344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.