ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2017
The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Pharmacogenetics and the Response to Antidepressants in Major Depressive Disorder.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Lipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study.BMC psychiatry · 2025Article
- Article
- Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?European archives of psychiatry and clinical neuroscience · 2025Article
- Review
- A network analysis of depressive symptoms and metabolomics.Psychological medicine · 2023Article
- Plasma lipidomic profile of depressive symptoms: a longitudinal study in a large sample of community-dwelling American Indians in the strong heart study.Molecular psychiatry · 2023Article
- Impact of St. John's wort extract Ze 117 on stress induced changes in the lipidome of PBMC.Molecular medicine (Cambridge, Mass.) · 2023Article
- Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis.Molecular psychiatry · 2023Article
- Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome.Frontiers in cellular neuroscience · 2023Article
- Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph).Translational psychiatry · 2022Article
- Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS.Frontiers in immunology · 2022Article
- Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder.Frontiers in pharmacology · 2022Article
- A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.Molecular psychiatry · 2021Article
- Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse.Translational psychiatry · 2021Article
- Article
- Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia.Biomolecules · 2021Article
- Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.Translational psychiatry · 2021Article
- Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe lipidome is rapidly garnering interest in the field of psychiatry. Recent studies have implicated lipidomic changes across numerous psychiatric disorders. In particular, there is growing evidence that the concentrations of several classes of lipids are altered in those diagnosed with MDD. However, for lipidomic abnormalities to be considered potential treatment targets for MDD (rather than secondary manifestations of the disease), a shared etiology between lipid concentrations and MDD should be demonstrated.
methodsIn a sample of 567 individuals from 37 extended pedigrees (average size 13.57 people, range=3-80), we used mass spectrometry lipidomic measures to evaluate the genetic overlap between twenty-three biologically distinct lipid classes and a dimensional scale of MDD.
resultsWe found that the lipid class with the largest endophenotype ranking value (ERV, a standardized parametric measure of pleiotropy) were ether-phosphodatidylcholines (alkylphosphatidylcholine, PC(O) and alkenylphosphatidylcholine, PC(P) subclasses). Furthermore, we examined the cluster structure of the twenty-five species within the top-ranked lipid class, and the relationship of those clusters with MDD. This analysis revealed that species containing arachidonic acid generally exhibited the greatest degree of genetic overlap with MDD.
conclusionsThis study is the first to demonstrate a shared genetic etiology between MDD and ether-phosphatidylcholine species containing arachidonic acid, an omega-6 fatty acid that is a precursor to inflammatory mediators, such as prostaglandins. The study highlights the potential utility of the well-characterized linoleic/arachidonic acid inflammation pathway as a diagnostic marker and/or treatment target for MDD.
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