ArticleNeuroImage2017
Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Brainbuilder: a software pipeline for 3D reconstruction of cortical maps from multi-modal 2D data sets.Communications biology · 2025Article
- Neurobiology and Impact of Chronic Traumatic Encephalopathy in Athletes: A Focused Review.Cureus · 2025Review
- Tensor image registration library: Deformable registration of stand-alone histology images to whole-brain post-mortem MRI data.NeuroImage · 2023Article
- Depicting the anatomy of the gyral white matter:Brain communications · 2023Review
- Correspondence of mean apparent propagator MRI metrics with phosphorylated tau and astrogliosis in chronic traumatic encephalopathy.Brain communications · 2023Article
- Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol.Journal of neurotrauma · 2022Article
- Mapping the human corticoreticular pathway with multimodal delineation of the gigantocellular reticular nucleus and high-resolution diffusion tractography.Journal of the neurological sciences · 2022Article
- Review
- Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.Journal of neurotrauma · 2021Article
- Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management.Biomedicines · 2021Review
- Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective.Frontiers in neuroscience · 2020Article
- 7 Tesla MRI of the ex vivo human brain at 100 micron resolution.Scientific data · 2019Article
- Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.Journal of neurotrauma · 2019Article
- Histological validation of diffusion MRI fiber orientation distributions and dispersion.NeuroImage · 2018Article
- Design and validation of diffusion MRI models of white matter.Frontiers in physics · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Advanced diffusion MRI methods have recently been proposed for detection of pathologies such as traumatic axonal injury and chronic traumatic encephalopathy which commonly affect complex cortical brain regions. However, radiological-pathological correlations in human brain tissue that detail the relationship between the multi-component diffusion signal and underlying pathology are lacking. We present a nonlinear voxel based two dimensional coregistration method that is useful for matching diffusion signals to quantitative metrics of high resolution histological images. When validated in ex vivo human cortical tissue at a 250×250×500 μm spatial resolution, the method proved robust in correlations between generalized q-sampling imaging and histologically based white matter fiber orientations, with r=0.94 for the primary fiber direction and r=0.88 for secondary fiber direction in each voxel. Importantly, however, the correlation was substantially worse with reduced spatial resolution or with fiber orientations derived using a diffusion tensor model. Furthermore, we have detailed a quantitative histological metric of white matter fiber integrity termed power coherence capable of distinguishing architecturally complex but intact white matter from disrupted white matter regions. These methods may allow for more sensitive and specific radiological-pathological correlations of neurodegenerative diseases affecting complex gray and white matter.
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Registered trials
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