ArticleSleep2017
Sleep Consolidates Motor Learning of Complex Movement Sequences in Mice.
Article in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- A synaptic locus of song learning.Nature · 2026Article
- Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity.bioRxiv : the preprint server for biology · 2026Article
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- Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling.Communications biology · 2026Article
- VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation.Science advances · 2025Article
- Associations Between REM Sleep-like Posture Expression and Cognitive Flexibility in 2-Month-Old Japanese Black Calves.Animals : an open access journal from MDPI · 2025Article
- Article
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- A Role for δ Subunit-Containing GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves.The Journal of cell biology · 2024Article
- Developmental coordination disorder: What can we learn from RI mice using motor learning tasks and QTL analysis.Genes, brain, and behavior · 2023Article
- Cortical circuit dynamics underlying motor skill learning: from rodents to humans.Frontiers in molecular neuroscience · 2023Review
- HippocampalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Performance-Dependent Consolidation of Learned Vocal Changes in Adult Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Coupling between motor cortex and striatum increases during sleep over long-term skill learning.eLife · 2021Article
- Waking experience modulates sleep need in mice.BMC biology · 2021Article
- Stress-induced sleep-like inactivity modulates stress susceptibility in mice.Scientific reports · 2020Article
- Multiple caffeine doses maintain vigilance, attention, complex motor sequence expression, and manual dexterity during 77 hours of total sleep deprivation.Neurobiology of sleep and circadian rhythms · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Introduction: Sleep-dependent consolidation of motor learning has been extensively studied in humans, but it remains unclear why some, but not all, learned skills benefit from sleep. Aims and Methods: Here, we compared 2 different motor tasks, both requiring the mice to run on an accelerating device. In the rotarod task, mice learn to maintain balance while running on a small rod, while in the complex wheel task, mice run on an accelerating wheel with an irregular rung pattern. Results: In the rotarod task, performance improved to the same extent after sleep or after sleep deprivation (SD). Overall, using 7 different experimental protocols (41 sleep deprived mice, 26 sleeping controls), we found large interindividual differences in the learning and consolidation of the rotarod task, but sleep before/after training did not account for this variability. By contrast, using the complex wheel, we found that sleep after training, relative to SD, led to better performance from the beginning of the retest session, and longer sleep was correlated with greater subsequent performance. As in humans, the effects of sleep showed large interindividual variability and varied between fast and slow learners, with sleep favoring the preservation of learned skills in fast learners and leading to a net offline gain in the performance in slow learners. Using Fos expression as a proxy for neuronal activation, we also found that complex wheel training engaged motor cortex and hippocampus more than the rotarod training. Conclusions: Sleep specifically consolidates a motor skill that requires complex movement sequences and strongly engages both motor cortex and hippocampus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.