ArticleSleep2017
Association of Restless Legs Syndrome With Incident Parkinson's Disease.
Article in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2025Guideline
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Risk of Parkinson Disease Among Patients With Restless Leg Syndrome.JAMA network open · 2025Article
- Restless legs syndrome in Parkinson's disease: epidemiology, pathogenetic overlaps, and clinical management.Journal of neurology · 2025Review
- Race and ethnicity matter! Moving Parkinson's risk research towards diversity and inclusiveness.NPJ Parkinson's disease · 2025Review
- Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review.Nature and science of sleep · 2025Review
- Longitudinal Studies of Sleep Disturbances in Parkinson's Disease.Current neurology and neuroscience reports · 2022Review
- Treatment of Depression with Vortioxetine in a Patient with Comorbid Major Depressive Disorder and Restless Legs Syndrome: A Case Report.Noro psikiyatri arsivi · 2022Article
- Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.Journal of Parkinson's disease · 2022Article
- Does Restless Legs Syndrome Have a Different Pathomechanism in Premotor and Motor Parkinson's Disease?Journal of movement disorders · 2021Article
- Sleep disorders and gout in Australian adults.BMC rheumatology · 2021Article
- Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Sleep Issues in Parkinson's Disease and Their Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease.Clinics in geriatric medicine · 2020Review
- Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Probable RBD Associates with the Development of RLS in Parkinson's Disease: A Cross-Sectional Study.Behavioural neurology · 2019Article
- Restless Legs Syndrome and Parkinson Disease: A Causal Relationship Between the Two Disorders?Frontiers in neurology · 2018Review
- Is there a Premotor Phase of Essential Tremor?Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Study Objectives: The association between restless legs syndrome (RLS) and Parkinson's disease (PD) has been extensively studied with inconclusive results; therefore, we prospectively examined the associations of the presence of RLS with development of incident PD. Methods: From a nationally representative prospective cohort of almost 3.5 million US veterans (age: 60 ± 14 years, 93% male, median follow-up time of 7.8 years [interquartile range: 6.4-8.4 years]), we created a propensity-matched cohort of 100882 PD-free patients and examined the association between prevalent RLS and incident PD. This association was also assessed in the entire cohort. Associations were examined using Cox models. Results: There were 68 incident PD events (0.13%, incidence rate 1.87 [1.48-2.37]/10000 patient-years) in the RLS-negative group, and 185 incident PD events (0.37%, incidence rate 4.72 [4.09-5.45]/10000 patient-years) in the RLS-positive group in the propensity-matched cohort. Prevalent RLS was associated with more than twofold higher risk of incident PD (hazard ratio [HR]: 2.57, 95% confidence interval [CI]: 1.95-3.39) compared to RLS-negative patients. Qualitatively similar results were found when we examined the entire 3.5 million cohort: Prevalent RLS was associated with more than twofold higher risk of incident PD (multivariable adjusted HR: 2.81, 95%CI: 2.41-3.27). Conclusion: RLS and PD share common risk factors. In this large cohort of US veterans, we found that prevalent RLS is associated with higher risk of incident PD during 8 years of follow-up, suggesting that RLS could be an early clinical feature of incident PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.