ReviewSleep2017
Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS.
Review in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Pooled it
- Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine.International journal of molecular sciences · 2023Pooled it
- Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.Oncotarget · 2017Pooled it
- Risk of excessive sleepiness in sleep restriction therapy and cognitive behavioral therapy for insomnia: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Circadian distribution of carbohydrate intake during adolescence and association with risk markers of type 2 diabetes in adulthood-the role of chronotype.European journal of nutrition · 2026Article
- Clock Gene Variants Are Associated with Energy and Macronutrient Intake in Early Childhood and Adulthood.Nutrients · 2026Article
- Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness-Eveningness Questionnaire.Scientific reports · 2026Observational
- Travel-Induced Circadian and Microbiota Disturbances: Implications for Athlete Health and Performance: A Narrative Review.Nutrients · 2026Review
- Emotion regulation and depressive symptoms mediate the association between chronotype and suicidality.Acta neuropsychiatrica · 2026Article
- Heart rate phase is an indicator of chronotype-relevant circadian shifts associated with human disease: an All of Us Research Program analysis.The Journal of physiology · 2026Article
- By dawn or dusk-how circadian timing rewrites bacterial infection outcomes.FEBS letters · 2026Review
- Associations between chronotype, physical activity and cognition in a free-living setting.Experimental brain research · 2026Article
- CircadianiScience · 2026Article
- Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications.Frontiers in sleep · 2026Review
- Chronotype-specific associations of sleep-wake schedule with behavioral, physiological, and psychological parameters.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Links between psychological distress, late chronotype, and impaired sleep quality in survivors of sexual assault.Frontiers in psychology · 2026Article
- Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025Article
- Associations between chronotype and psychiatric symptoms across the adult lifespan.Translational psychiatry · 2025Article
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- Chronotype and Mental Health: Are Late Sleepers More Vulnerable?Current psychiatry reports · 2025Review
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Study Objectives: Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related illnesses. Family studies indicate that chronotype is a heritable trait, thus directing attention toward its genetic basis. Although discoveries from molecular studies of candidate genes have shed light onto its genetic architecture, the contribution of genetic variation to chronotype has remained unclear with few related variants identified. In the advent of large-scale genome-wide association studies (GWAS), scientists now have the ability to discover novel common genetic variants associated with complex phenotypes. Three recent large-scale GWASs of chronotype were conducted on subjects of European ancestry from the 23andMe cohort and the UK Biobank. This review discusses the findings of these landmark GWASs in the context of prior research. Methods: We systematically reviewed and compared methodological and analytical approaches and results across the three GWASs of chronotype. Results: A good deal of consistency was observed across studies with 9 genes identified in 2 of the 3 GWASs. Several genes previously unknown to influence chronotype were identified. Conclusions: GWAS is an important tool in identifying common variants associated with the complex chronotype phenotype, the findings of which can supplement and guide molecular science. Future directions in model systems and discovery of rare variants are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.