Evidence map›Paper›PMID 28364424›Full record

ArticleSleep2017

Symptomless Multi-Variable Apnea Prediction Index Assesses Obstructive Sleep Apnea Risk and Adverse Outcomes in Elective Surgery.

M Melanie Lyons, Brendan T Keenan, Junxin Li, Tanya Khan, Nabil Elkassabany, Colleen M Walsh, Noel N Williams, Allan I Pack, Indira Gurubhagavatula

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Multisite validation of a simple electronic health record algorithm for identifying diagnosed obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  8. Big data: mind your Ps and Qs-the importance of precision and quality in data validation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  9. Article
  10. Review
  11. P4 medicine approach to obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

M Melanie LyonsCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Brendan T KeenanCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Junxin LiCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Tanya KhanPerelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Nabil ElkassabanySection of Orthopedic Anesthesiology, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Colleen M WalshCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA.
Noel N WilliamsPenn Metabolic and Bariatric Surgery Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Allan I PackCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Indira GurubhagavatulaCenter for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
University of Pennsylvania · USPhiladelphia VA Medical Center · US

Funding

Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
TRAINING PROGRAM/RESPIRATORY NEUROBIOLOGY AND SLEEPT32HL007713 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 1992 to 2022
$11.9M
NHLBI NIH HHS P01 HL094307NHLBI NIH HHS T32 HL007713
6 · The paper itself

Abstract

Study Objective: To validate that the symptomless Multi-Variable Apnea Prediction index (sMVAP) is associated with Obstructive Sleep Apnea (OSA) diagnosis and assess the relationship between sMVAP and adverse outcomes in patients having elective surgery. We also compare associations between Bariatric surgery, where preoperative screening for OSA risk is mandatory, and non-Bariatric surgery groups who are not screened routinely for OSA. Methods: Using data from 40 432 elective inpatient surgeries, we used logistic regression to determine the relationship between sMVAP and previous OSA, current hypertension, and postoperative complications: extended length of stay (ELOS), intensive-care-unit-stay (ICU-stay), and respiratory complications (pulmonary embolism, acute respiratory distress syndrome, and/or aspiration pneumonia). Results: Higher sMVAP was associated with increased likelihood of previous OSA, hypertension and all postoperative complications (p < .0001). The top sMVAP quintile had increased odds of postoperative complications compared to the bottom quintile. For ELOS, ICU-stay, and respiratory complications, respective odds ratios (95% CI) were: 1.83 (1.62, 2.07), 1.44 (1.32, 1.58), and 1.85 (1.37, 2.49). Compared against age-, gender- and BMI-matched patients having Bariatric surgery, sMVAP was more strongly associated with postoperative complications in non-Bariatric surgical groups, including: (1) ELOS (Orthopedics [p < .0001], Gastrointestinal [p = .024], Neurosurgery [p = .016], Spine [p = .016]); (2) ICU-stay (Orthopedics [p = .0004], Gastrointestinal [p < .0001], and Otorhinolaryngology [p = .0102]); and (3) respiratory complications (Orthopedics [p =.037] and Otorhinolaryngology [p =.011]). Conclusions: OSA risk measured by sMVAP correlates with higher risk for select postoperative complications. Associations are stronger for non-Bariatric surgeries, where preoperative screening for OSA is not routinely performed. Thus, preoperative screening may reduce OSA-related risk for adverse postoperative outcomes.

Indexed as

AdultBariatric SurgeryElective Surgical ProceduresFemaleHumansHypertensionIntensive Care UnitsLength of StayMaleMiddle AgedObesity, MorbidOdds RatioPostoperative ComplicationsPreoperative CareRisk FactorsSleep Apnea, ObstructiveAdverse Outcomes.Elective SurgeryObstructive Sleep ApneaObstructive Sleep Apnea RiskPostoperative ComplicationsSymptomless Multi-Variable Apnea Prediction

Identifiers

PMID28364424
PMCPMC5806575
OpenAlexW2591760513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.