Trial reportSleep2017
Using Oscillating Sounds to Manipulate Sleep Spindles.
Trial report in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps.Communications biology · 2026Article
- Thalamic transcranial electrical stimulation with temporal interference enhances sleep spindle activity during a daytime nap.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- Using a wearable EEG device to examine age trends in sleep macro- and micro-architecture across adolescence.bioRxiv : the preprint server for biology · 2025Article
- Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sleep Consolidation Potentiates Sensorimotor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A personalized semi-automatic sleep spindle detection (PSASD) framework.Journal of neuroscience methods · 2024Article
- Automatic sleep spindles identification and classification with multitapers and convolution.Sleep · 2024Article
- Effect of transcranial direct current stimulation and narrow-band auditory stimulation on the intraoperative electroencephalogram: an exploratoratory feasibility study.Frontiers in psychiatry · 2024Article
- Sleep Spindles Favor Emotion Regulation Over Memory Consolidation of Stressors in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Improving memory via automated targeted memory reactivation during sleep.Journal of sleep research · 2022Article
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- The Brain Selectively Tunes to Unfamiliar Voices during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effects of pleasant sound on overnight sleep condition: A crossover randomized study.Frontiers in sleep · 2022Article
- Infra-low frequency neurofeedback and insomnia as a model of CNS dysregulation.Frontiers in human neuroscience · 2022Review
- Visuomotor Adaptation Modulates the Clustering of Sleep Spindles Into Trains.Frontiers in neuroscience · 2022Article
- Sleep Spindles Preferentially Consolidate Weakly Encoded Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better.Annual review of psychology · 2021Article
- Sounding It Out: Auditory Stimulation and Overnight Memory Processing.Current sleep medicine reports · 2021Review
- Dream engineering: Simulating worlds through sensory stimulation.Consciousness and cognition · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Introduction: EEG oscillations known as sleep spindles have been linked with various aspects of cognition, but the specific functions they signal remain controversial. Two types of EEG sleep spindles have been distinguished: slow spindles at 11-13.5 Hz and fast spindles at 13.5-16 Hz. Slow spindles exhibit a frontal scalp topography, whereas fast spindles exhibit a posterior scalp topography and have been preferentially linked with memory consolidation during sleep. To advance understanding beyond that provided from correlative studies of spindles, we aimed to develop a new method to systematically manipulate spindles. Aims and Methods: We presented repeating bursts of oscillating white noise to people during a 90-min afternoon nap. During stage 2 and slow-wave sleep, oscillations were embedded within contiguous 10-s stimulation intervals, each comprising 2 s of white noise amplitude modulated at 12 Hz (targeting slow spindles), 15 Hz (targeting fast spindles), or 50 Hz followed by 8 s of constant white noise. Results: During oscillating stimulation compared to constant stimulation, parietal EEG recordings showed more slow spindles in the 12-Hz condition, more fast spindles in the 15-Hz condition, and no change in the 50-Hz control condition. These effects were topographically selective, and were absent in frontopolar EEG recordings, where slow spindle density was highest. Spindles during stimulation were similar to spontaneous spindles in standard physiological features, including duration and scalp distribution. Conclusions: These results define a new method to selectively and noninvasively manipulate spindles through acoustic resonance, while also providing new evidence for functional distinctions between the 2 types of EEG spindles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.