ArticleThe Journal of cell biology1988
Differential regulation of Paramecium ciliary motility by cAMP and cGMP.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 112 citations in OpenAlex.
- Heterogeneity of radial spoke components in Tetrahymena cilia.Cellular and molecular life sciences : CMLS · 2025Article
- Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency.Nature communications · 2025Article
- Mechanoresponses mediated by the TRP11 channel in cilia ofiScience · 2023Article
- Establishing a High-Throughput Locomotion Tracking Method for Multiple Biological Assessments inCells · 2022Article
- Characterization of the cAMP phosphodiesterase domain in plant adenylyl cyclase/cAMP phosphodiesterase CAPE from the liverwort Marchantia polymorpha.Journal of plant research · 2022Article
- Review
- Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform.Scientific reports · 2016Article
- Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.Biochimica et biophysica acta · 2015Article
- Cell-cell signalling in sexual chemotaxis: a basis for gametic differentiation, mating types and sexes.Journal of the Royal Society, Interface · 2015Article
- Cyclic GMP and Cilia Motility.Cells · 2015Review
- Review
- Inactivation of Ca2+-induced ciliary reversal by high-salt extraction in the cilia of Paramecium.Protoplasma · 2013Article
- Outer dynein arm light chain 1 is essential for controlling the ciliary response to cyclic AMP in Paramecium tetraurelia.Eukaryotic cell · 2012Article
- Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.Archives of biochemistry and biophysics · 2011Review
- The paraflagellar rod of kinetoplastid parasites: from structure to components and function.International journal for parasitology · 2010Review
- Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum.The Journal of biological chemistry · 2009Article
- Radial spoke proteins of Chlamydomonas flagella.Journal of cell science · 2006Article
- Multigene family encoding 3',5'-cyclic-GMP-dependent protein kinases in Paramecium tetraurelia cells.Eukaryotic cell · 2006Article
- Bend propagation drives central pair rotation in Chlamydomonas reinhardtii flagella.The Journal of cell biology · 2004Article
- Flagellar radial spokes contain a Ca2+-stimulated nucleoside diphosphate kinase.Molecular biology of the cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
cAMP and cGMP had distinct effects on the regulation of ciliary motility in Paramecium. Using detergent-permeabilized cells reactivated to swim with MgATP, we observed effects of cyclic nucleotides and interactions with Ca2+ on the swimming speed and direction of reactivated cells. Both cAMP and cGMP increased forward swimming speed two- to threefold with similar half-maximal concentrations near 0.5 microM. The two cyclic nucleotides, however, had different effects in antagonism with the Ca2+ response of backward swimming and on the handedness of the helical swimming paths of reactivated cells. These results suggest that cAMP and cGMP differentially regulate the direction of the ciliary power stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.