ReviewIntensive care medicine2017
Acute kidney injury in sepsis.
Review in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 409 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients, Randomized Control Trial
Effect of Intravenous Vitamin C on Sequential Organ Failure Assessment (SOFA) Score Among Septic Patients: Randomized Controlled Trial
Who cites it
409 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Timing of renal-replacement therapy in patients with acute kidney injury and sepsis: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Association Between Acute Gastrointestinal Injury and Mortality Risk in Critically Ill Patients: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2026Pooled it
- Shared genetic correlations between kidney diseases and sepsis.Frontiers in endocrinology · 2024Pooled it
- The predictive value of [TIMP-2]*[IGFBP7] in adverse outcomes for acute kidney injury: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients.Renal failure · 2023Trial
- Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial.Critical care (London, England) · 2023Trial
- IL-18-associated basophil and mast cell activation in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- URB597 attenuates experimental sepsis-associated acute kidney injury with reduced renal inflammation, apoptosis, and TLR4/NF-κB activation.Molecular biology reports · 2026Article
- Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence.Intensive care medicine experimental · 2026Article
- Mineralocorticoid magic? Evaluating fludrocortisone in septic shock.British journal of clinical pharmacology · 2026Review
- Incidence, time trends and predictors of acute kidney injury in the region of Stockholm, Sweden.Scientific reports · 2026Article
- Optimal Dynamic Treatment Regimes for High-Dimensional Accelerated Failure Time Model.Statistics in medicine · 2026Article
- Nanomachines Based on Inner Ultrasonic Multiple Scattering for Ameliorating Renal Function.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- Association between blood urea nitrogen to albumin ratio and 28-day mortality of acute heart failure in intensive care unit: analysis based on MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Machine learning for prognostic assessment in elderly patients with gastroduodenal perforation.BMC surgery · 2026Article
- Risk Factors for Upper Urinary Tract Stone Recurrence: A Retrospective Study of 247 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Illness severity modifies the association between sepsis and survival in critically ill patients with acute kidney injury.Clinical and experimental nephrology · 2026Article
- A new murine gram-negative sepsis model with standard care satisfies Sepsis-3 and reproduces clinical pathology.Intensive care medicine experimental · 2026Article
- Integrating metabolomics and machine learning with in silico analysis to identify early biomarkers and molecular interactions in sepsis-associated acute kidney injury.Scientific reports · 2026Article
349 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such AKI. Its pathophysiology remains poorly understood, but animal models and lack of histological changes suggest that, at least initially, septic AKI may be a functional phenomenon with combined microvascular shunting and tubular cell stress. The diagnosis remains based on clinical assessment and measurement of urinary output and serum creatinine. However, multiple biomarkers and especially cell cycle arrest biomarkers are gaining acceptance. Prevention of septic AKI remains based on the treatment of sepsis and on early resuscitation. Such resuscitation relies on the judicious use of both fluids and vasoactive drugs. In particular, there is strong evidence that starch-containing fluids are nephrotoxic and decrease renal function and suggestive evidence that chloride-rich fluid may also adversely affect renal function. Vasoactive drugs have variable effects on renal function in septic AKI. At this time, norepinephrine is the dominant agent, but vasopressin may also have a role. Despite supportive therapies, renal function may be temporarily or completely lost. In such patients, renal replacement therapy (RRT) becomes necessary. The optimal intensity of this therapy has been established, while the timing of when to commence RRT is now a focus of investigation. If sepsis resolves, the majority of patients recover renal function. Yet, even a single episode of septic AKI is associated with increased subsequent risk of chronic kidney disease.
Indexed as
Identifiers
28364303What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.